Editing TATA box (section)

=== Technology ===
Many of the studies so far have been performed [[in vitro]], providing only a prediction of what may happen not a real-time representation of what is happening in the [[Cell (biology)|cells]]. Recent studies in 2016 have been done to demonstrate TATA-binding activity [[in vivo]]. Core [[Promoter (genetics)|promoter]]-specific mechanisms for transcription initiation by the canonical TBP/TFIID-dependent basal [[Transcription (biology)|transcription]] machinery has recently been documented [[in vivo]] showing the activation by [[Serum response factor|SRF]]-dependent [[Upstream activating sequence|upstream activating sequence (UAS)]] of the human [[ACTB (gene)|ACTB gene]] involved in TATA-binding.<ref name=":16">{{cite journal | vauthors = Xu M, Gonzalez-Hurtado E, Martinez E | title = Core promoter-specific gene regulation: TATA box selectivity and Initiator-dependent bi-directionality of serum response factor-activated transcription | journal = Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms | volume = 1859 | issue = 4 | pages = 553–63 | date = April 2016 | pmid = 26824723 | pmc = 4818687 | doi = 10.1016/j.bbagrm.2016.01.005 }}</ref>