Editing Brain-derived neurotrophic factor (section)

=== Schizophrenia ===
{{See also|Epigenetics of schizophrenia#Methylation of BDNF}}
Preliminary studies have assessed a possible relationship between [[schizophrenia]] and BDNF.<ref>{{cite journal | vauthors = Xiong P, Zeng Y, Wu Q, Han Huang DX, Zainal H, Xu X, Wan J, Xu F, Lu J | title = Combining serum protein concentrations to diagnose schizophrenia: a preliminary exploration | journal = The Journal of Clinical Psychiatry | volume = 75 | issue = 8 | pages = e794–801 | date = August 2014 | pmid = 25191916 | doi = 10.4088/JCP.13m08772 }}</ref> It has been shown that BDNF mRNA levels are decreased in cortical layers IV and V of the dorsolateral prefrontal cortex of schizophrenic patients, an area associated with working memory.<ref>{{cite journal | vauthors = Ray MT, Shannon Weickert C, Webster MJ | title = Decreased BDNF and TrkB mRNA expression in multiple cortical areas of patients with schizophrenia and mood disorders | journal = Translational Psychiatry | volume = 4 | issue = 5 | pages = e389 | date = May 2014 | pmid = 24802307 | pmc = 4035720 | doi = 10.1038/tp.2014.26 }}</ref>