Editing Cannabinoid (section)

=== Separation ===
Cannabinoids can be separated from the plant by [[solvent extraction|extraction]] with organic [[solvent]]s. [[Hydrocarbon]]s and [[Alcohol (chemistry)|alcohols]] are often used as solvents. However, these solvents are flammable and many are toxic.<ref>{{cite journal |vauthors=Romano LL, Hazekamp A |title=Cannabis Oil: chemical evaluation of an upcoming cannabis-based medicine |journal=Cannabinoids |date=2013 |volume=7 |issue=1 |pages=1–11 |url=http://www.cannabis-med.org/data/pdf/en_2013_01_1.pdf |access-date=2017-12-07 |archive-date=2017-12-15 |archive-url=https://web.archive.org/web/20171215093111/http://www.cannabis-med.org/data/pdf/en_2013_01_1.pdf |url-status=live }}</ref> Butane may be used, which evaporates extremely quickly. Supercritical solvent extraction with [[carbon dioxide]] is an alternative technique. Once extracted, isolated components can be separated using wiped film vacuum distillation or other [[distillation]] techniques.<ref>{{cite journal| vauthors = Rovetto LJ, Aieta NV |title=Supercritical carbon dioxide extraction of cannabinoids from Cannabis sativa L.|journal=The Journal of Supercritical Fluids|date=November 2017|volume=129|pages=16–27|doi=10.1016/j.supflu.2017.03.014|hdl=11336/43849|hdl-access=free}}</ref> Also, techniques such as SPE or SPME are found useful in the extraction of these compounds.<ref>{{cite journal| vauthors = Jain R, Singh R |title=Microextraction techniques for analysis of cannabinoids|journal=TrAC Trends in Analytical Chemistry|volume=80|pages=156–166|doi=10.1016/j.trac.2016.03.012|year=2016}}</ref>