Editing Diamond anvil cell (section)

===Principle===
The pressure transmitting medium is an important component in any high-pressure experiment. The medium fills the space within the sample 'chamber' and applies the pressure being transmitted to the medium onto the sample. In a good high-pressure experiment, the medium should maintain a homogeneous distribution of pressure on the sample. In other words, the medium must stay hydrostatic to ensure uniform compressibility of the sample. Once a pressure transmitting medium has lost its hydrostaticity, a pressure gradient forms in the chamber that increases with increasing pressure. This gradient can greatly affect the sample, compromising results. The medium must also be inert, as to not interact with the sample, and stable under high pressures. For experiments with laser heating, the medium should have low thermal conductivity. If an optical technique is being employed, the medium should be optically transparent and for x-ray diffraction, the medium should be a poor x-ray scatterer – as to not contribute to the signal.

Some of the most commonly used pressure transmitting media have been sodium chloride, silicone oil, and a 4:1&nbsp;methanol-ethanol mixture. Sodium chloride is easy to load and is used for high-temperature experiments because it acts as a good thermal insulator. The methanol-ethanol mixture displays good hydrostaticity to about 10&nbsp;GPa and with the addition of a small amount of water can be extended to about 15&nbsp;GPa.<ref name="jay" />

For pressure experiments that exceed 10&nbsp;GPa, noble gases are preferred. The extended hydrostaticity greatly reduces the pressure gradient in samples at high pressure. Noble gases, such as helium, neon, and argon are optically transparent, thermally insulating, have small X-ray scattering factors, and have good hydrostaticity at high pressures. Even after solidification, noble gases provide quasihydrostatic environments.

Argon is used for experiments involving laser heating because it is chemically insulating. Since it condenses at a temperature above that of liquid nitrogen, it can be loaded cryogenically. Helium and neon have low X-ray scattering factors and are thus used for collecting X-ray diffraction data. Helium and neon also have low shear moduli; minimizing strain on the sample.<ref name="riv">{{cite journal |author1=Rivers, M. |author2=Prakapenka, V.B. |author3=Kubo, A. |author4=Pullins, C. |author5=Holl, C. |author6=Jacobson, S. |title=The COMPRES/GSECARS gas-loading system for diamond anvil cells at the Advanced Photon Source |year=2008 |journal=High Pressure Research |volume=28 |issue=3 |pages=273–292 |bibcode=2008HPR....28..273R |doi=10.1080/08957950802333593|s2cid=11986700 }}</ref> These two noble gases do not condense above that of liquid nitrogen and cannot be loaded cryogenically. Instead, a high-pressure gas loading system has been developed that employs a gas compression method.<ref name="Uch">{{cite journal |author1=Uchida, T. |author2=Funamori, N. |author3=Yagi, T. |title=Lattice strains in crystals under uniaxial stress field |year=1996 |journal=Journal of Applied Physics |volume=80 |issue=2 |page=739 |bibcode=1996JAP....80..739U |doi=10.1063/1.362920}}</ref>