Editing Extracellular matrix (section)

====Effect on gene expression====
Differing mechanical properties in ECM exert effects on both cell behaviour and [[gene expression]].<ref>{{cite journal |last1=Wahbi |first1=Wafa |last2=Naakka |first2=Erika |last3=Tuomainen |first3=Katja |last4=Suleymanova |first4=Ilida |last5=Arpalahti |first5=Annamari |last6=Miinalainen |first6=Ilkka |last7=Vaananen |first7=Juho |last8=Grenman |first8=Reidar |last9=Monni |first9=Outi |last10=Al-Samadi |first10=Ahmed |last11=Salo |first11=Tuula |title=The critical effects of matrices on cultured carcinoma cells: Human tumor-derived matrix promotes cell invasive properties |journal=Experimental Cell Research |date=February 2020 |volume=389 |issue=1 |pages=111885 |doi=10.1016/j.yexcr.2020.111885 |pmid=32017929 |hdl=10138/325579 |s2cid=211035510 |url=http://urn.fi/urn:nbn:fi-fe2020051435636 |hdl-access=free }}</ref> Although the mechanism by which this is done has not been thoroughly explained, [[Hemidesmosome|adhesion complexes]] and the [[actin]]-[[myosin]] [[cytoskeleton]], whose contractile forces are transmitted through transcellular structures are thought to play key roles in the yet to be discovered molecular pathways.<ref name="DischerDE"/>