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NMDA receptor
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==== Neramexane ==== [[File:Neramexane.svg|thumb|right|'''Figure 6:''' Chemical structure of neramexane, second generation memantine derivative]] An example of memantine derivative is [[neramexane]] which was discovered by studying number of aminoalkyl [[cyclohexanes]], with memantine as the template, as NMDA receptor antagonists. Neramexane binds to the same site as memantine within the NMDA receptor associated channel and with comparable affinity. It does also show very similar bioavailability and blocking kinetics [[in vivo]] as memantine. Neramexane went to [[clinical trials]] for four indications, including Alzheimer's disease.<ref name="Wanka" />
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