Editing Prostate-specific antigen (section)

== Interactions ==

Prostate-specific antigen has been shown to [[Protein–protein interaction|interact]] with [[protein C inhibitor]].<ref name="Christensson-1994">{{cite journal | vauthors = Christensson A, Lilja H | title = Complex formation between protein C inhibitor and prostate-specific antigen in vitro and in human semen | journal = European Journal of Biochemistry | volume = 220 | issue = 1 | pages = 45–53 | date = February 1994 | pmid = 7509746 | doi = 10.1111/j.1432-1033.1994.tb18597.x }}</ref><ref name="Kise-1996">{{cite journal | vauthors = Kise H, Nishioka J, Kawamura J, Suzuki K | title = Characterization of semenogelin II and its molecular interaction with prostate-specific antigen and protein C inhibitor | journal = European Journal of Biochemistry | volume = 238 | issue = 1 | pages = 88–96 | date = May 1996 | pmid = 8665956 | doi = 10.1111/j.1432-1033.1996.0088q.x | doi-access = free }}</ref>
Prostate-specific antigen interacts with and activates the vascular endothelial growth factors [[VEGF-C]] and [[VEGF-D]], which are involved in tumor [[angiogenesis]] and in the lymphatic [[metastasis]] of tumors.<ref>{{cite journal | vauthors = Jha SK, Rauniyar K, Chronowska E, Mattonet K, Maina EW, Koistinen H, Stenman UH, Alitalo K, Jeltsch M | title = KLK3/PSA and cathepsin D activate VEGF-C and VEGF-D | journal = eLife | volume = 8 | pages = –44478 | date = May 2019 | pmid = 31099754 | pmc = 6588350 | doi = 10.7554/eLife.44478 | doi-access = free }}</ref>