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Botulinum toxin
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===Economics=== {{Update|date=October 2017}} {{As of|2018}}, botulinum toxin injections are the most common cosmetic operation, with 7.4 million procedures in the United States, according to the [[American Society of Plastic Surgeons]].<ref>{{cite web |url=https://www.plasticsurgery.org/news/press-releases/new-plastic-surgery-statistics-reveal-trends-toward-body-enhancement |title=New plastic surgery statistics reveal trends toward body enhancement |date=11 March 2019 |website=Plastic Surgery |archive-url=https://web.archive.org/web/20190312062815/https://www.plasticsurgery.org/news/press-releases/new-plastic-surgery-statistics-reveal-trends-toward-body-enhancement |archive-date=12 March 2019}}</ref> The global market for botulinum toxin products, driven by their cosmetic applications, was forecast to reach $2.9 billion by 2018. The facial aesthetics market, of which they are a component, was forecast to reach $4.7 billion ($2 billion in the US) in the same timeframe.<ref>{{cite web |url=http://www.companiesandmarkets.com/News/Healthcare-and-Medical/The-global-botox-market-forecast-to-reach-2-9-billion-by-2018/NI2991 |title=The global botox market forecast to reach $2.9 billion by 2018 |date=10 May 2012 |access-date=5 October 2012 |vauthors=Chapman L |archive-url=https://web.archive.org/web/20120806230249/http://www.companiesandmarkets.com/News/Healthcare-and-Medical/The-global-botox-market-forecast-to-reach-2-9-billion-by-2018/NI2991 |archive-date=6 August 2012 |url-status=dead}}</ref> ====US market==== In 2020, 4,401,536 botulinum toxin Type A procedures were administered.<ref>{{cite web |title=2020 National Plastic Surgery Statistics: Cosmetic Surgical Procedures |url=https://www.plasticsurgery.org/documents/News/Statistics/2020/plastic-surgery-statistics-report-2020.pdf |publisher=American Society of Plastic Surgeons |access-date=22 May 2021 |archive-date=23 June 2021 |archive-url=https://web.archive.org/web/20210623232536/https://www.plasticsurgery.org/documents/News/Statistics/2020/plastic-surgery-statistics-report-2020.pdf |url-status=live }}</ref> In 2019 the botulinum toxin market made US$3.19 billion.<ref name="FBI">{{cite web |title=Botulinum Toxin Market |url=https://www.fortunebusinessinsights.com/industry-reports/botulinum-toxin-market-100996 |work=Fortune Business Insights |access-date=22 May 2021 |archive-date=27 June 2021 |archive-url=https://web.archive.org/web/20210627192718/https://www.fortunebusinessinsights.com/industry-reports/botulinum-toxin-market-100996 |url-status=live }}</ref> ====Botox cost==== Botox cost is generally determined by the number of units administered (avg. $10β30 per unit) or by the area ($200β1000) and depends on the physician's expertise, clinic location, number of units, and treatment complexity.<ref>{{Cite web |title=How Much Does Botox Cost |url=https://www.cosmeticassociation.org/cosmetic-procedures/botox/how-much-does-botox-cost/ |access-date=13 March 2013 |website=American Cosmetic Association |archive-date=13 March 2023 |archive-url=https://web.archive.org/web/20230313122938/https://www.cosmeticassociation.org/cosmetic-procedures/botox/how-much-does-botox-cost/ |url-status=live }}</ref> ====Insurance==== In the US, Botox for medical purposes is usually covered by insurance if deemed medically necessary by a doctor and covers a plethora of medical problems including overactive bladder (OAB), urinary incontinence due to neurologic conditions, headaches and migraines, TMJ, spasticity in adults, cervical dystonia in adults, severe axillary hyperhidrosis (or other areas of the body), blepharospasm, upper or lower limb spasticity.<ref>{{cite web |title=Medicare Guidelines for Botox Treatments |url=https://www.medicarefaq.com/faqs/medicare-coverage-for-botox-treatments |work=MedicareFAQ.com |date=27 September 2021 |access-date=22 May 2021 |archive-date=23 May 2021 |archive-url=https://web.archive.org/web/20210523024145/https://www.medicarefaq.com/faqs/medicare-coverage-for-botox-treatments/ |url-status=live }}</ref><ref>{{cite web |title=BOTOX (onabotulinumtoxinA) for injection, for intramuscular, intradetrusor, or intradermal use |work=Highlights of Prescribing Information |url=https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/103000s5302lbl.pdf |publisher=U.S. [[Food and Drug Administration]] (FDA) |access-date=22 May 2021 |archive-date=28 March 2021 |archive-url=https://web.archive.org/web/20210328131433/https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/103000s5302lbl.pdf |url-status=live }}</ref> ====Cosmetic==== Botox's potential to reduce facial wrinkles was discovered in the 1990s, leading to its FDA approval for cosmetic use in 2002. Standard areas for aesthetics Botox injections include areas on the face or neck that can form fine lines and wrinkles due to every day muscle contractions and/or facial expressions such as smiling, frowning, squinting, and raising eyebrows. These areas include the glabellar region between the eyebrows, horizontal lines on the forehead, crow's feet around the eyes, and even circular bands that form around the neck secondary to platysmal hyperactivity.<ref>{{cite web | vauthors = Cosentino S |title=What Is Botox |website=Empire Medical Training |date=2021-02-13 |url=https://www.empiremedicaltraining.com/blog/what-is-botox/ |access-date=2025-05-01}}</ref> ====Hyperhidrosis==== Botox for excessive sweating is FDA approved.<ref name="pmid20418969">{{cite journal |vauthors = Nigam PK, Nigam A |title = Botulinum toxin |journal = Indian Journal of Dermatology |volume = 55 |issue = 1 |pages = 8β14 |date = 2010 |pmid = 20418969 |pmc = 2856357 |doi = 10.4103/0019-5154.60343 |doi-access = free }}</ref>
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