Editing Cannabinoid (section)

=== History ===
The first discovery of an individual cannabinoid was made, when British chemist [[Robert W. Cahn|Robert S. Cahn]] reported the partial structure of Cannabinol (CBN), which he later identified as fully formed in 1940.

Two years later, in 1942,<ref>{{Cite web|url=https://issuu.com/freedomleaf/docs/freedomleafissue34issuu|title=U.S. Chemist Roger Adams Isolated CBD 75 Years Ago|vauthors=Weinberg B|date=Fall 2018|website=Freedom Leaf|via=Issuu.com|access-date=2019-03-16|edition=34|archive-date=2019-04-06|archive-url=https://web.archive.org/web/20190406122157/https://issuu.com/freedomleaf/docs/freedomleafissue34issuu|url-status=live}}</ref> American chemist, [[Roger Adams]], made history when he discovered Cannabidiol (CBD).<ref>{{Cite web|url=https://cbdorigin.com/history-of-cbd/|title=The History Of CBD – A Brief Overview|vauthors=Cadena A|date=2019-03-08|website=CBD Origin|publisher=CBDOrigin.com|access-date=2019-03-16|archive-date=2019-06-06|archive-url=https://web.archive.org/web/20190606164902/https://cbdorigin.com/history-of-cbd/|url-status=live}}</ref> Progressing from Adams research, in 1963<ref name=":2">{{cite journal | vauthors = Pertwee RG | title = Cannabinoid pharmacology: the first 66 years | journal = British Journal of Pharmacology | volume = 147 | issue = Suppl 1 | pages = S163–S171 | date = January 2006 | pmid = 16402100 | pmc = 1760722 | doi = 10.1038/sj.bjp.0706406 }}</ref> Israeli professor Raphael Mechoulam<ref>{{Cite web|url=https://cannabinoids.huji.ac.il/people/raphael-mechoulam|title=Raphael Mechoulam Ph.D.|vauthors=Mechoulam R|website=cannabinoids.huji.ac.il|publisher=The Hebrew University of Jerusalem|type=Biography|access-date=2019-03-16|archive-date=2019-04-02|archive-url=https://web.archive.org/web/20190402090908/https://cannabinoids.huji.ac.il/people/raphael-mechoulam|url-status=live}}</ref> later identified the [[stereochemistry]] of CBD. The following year, in 1964,<ref name=":2" /> Mechoulam and his team identified the stereochemistry of Tetrahydrocannabinol (THC).{{citation needed|date=December 2013}}

Due to molecular similarity and ease of synthetic conversion, CBD was originally believed to be a natural precursor to THC. However, it is now known that CBD and THC are produced independently in the Cannabis plant from the precursor CBG.{{citation needed|date=December 2013}}

==== Emergence of derived psychoactive cannabis products ====
{{Further|Delta-8-Tetrahydrocannabinol#Legality_in_the_United_States}}
The [[Agriculture Improvement Act of 2018]] has been interpreted as allowing any hemp-derived product not exceeding 0.3% '''Δ<sup>9</sup>-THC''' to be sold legally in the US. Because the law limited only Δ<sup>9</sup>-THC levels, many other cannabinoids are generally considered legal to sell and are widely available in stores and online, including [[Delta-8-Tetrahydrocannabinol|Δ<sup>8</sup>-THC]], [[Delta-10-Tetrahydrocannabinol|Δ<sup>10</sup>-THC]], [[Hexahydrocannabinol|HHC]], and [[THCP]],<ref>{{cite web | vauthors = Florko N |title=How I found 'Trips Ahoy' and 'Blackberry Diesel' 'weed' vapes in a state where marijuana is very much illegal |url=https://www.statnews.com/2023/02/23/easy-to-buy-thc-0-hhc-even-where-marijuana-illegal/ |website=statnews.com |date=23 February 2023 |publisher=Stat |access-date=2 April 2023 |archive-date=2 April 2023 |archive-url=https://web.archive.org/web/20230402060523/https://www.statnews.com/2023/02/23/easy-to-buy-thc-0-hhc-even-where-marijuana-illegal/ |url-status=live }}</ref><ref>{{Cite web|date=2020-07-09|title=Delta 8 THC: Everything You Need To Know|url=https://www.laweekly.com/delta-8-thc-everything-you-need-to-know/|access-date=2020-07-14|website=LA Weekly|language=en-US|archive-date=2020-07-10|archive-url=https://web.archive.org/web/20200710111113/https://www.laweekly.com/delta-8-thc-everything-you-need-to-know/|url-status=live}}</ref> but have not had the same in-depth research that the Δ<sup>9</sup> isomer has on the human body; carrying potential risks in the short- or long-term. Other concerns include difficulties for [[drug testing]] due to novel [[metabolite]]s, or high potency/[[binding affinity]] of isomers for [[cannabinoid receptor]]s showing potential for [[Substance abuse|abuse]] (i.e., THCP, which has 33× the binding affinity of Δ<sup>9</sup>-THC)<ref>{{cite web |title=The problems with Cannabinoid Analogs (Delta-8 THC, Delta-10 THC and CBD) and their metabolites detectability in urine drug testing for potential cannabinoid abuse. |url=https://nij.ojp.gov/funding/awards/15pnij-21-gg-04188-ress |website=National Institute of Justice |publisher=USDOJ |access-date=20 July 2023 |language=en |date=9 December 2021}}</ref><ref>{{cite web |last1=Nagarkatti |first1=Prakash |last2=Nagarkatti |first2=Mitzi |title=Cannabis-derived products like delta-8 THC and delta-10 THC have flooded the US market |url=https://sc.edu/uofsc/posts/2023/04/conversation_cannabis_derived_products.php |website=University of South Carolina |publisher=USC |access-date=29 May 2023 |language=en |date=28 April 2023}}</ref> From 2021 to 2023, the Δ<sup>8</sup>-THC market generated US$2 billion in revenue.<ref>{{cite web | vauthors = Sabaghi D |title=Delta-8 THC Generated $2 Billion In Revenue In Two Years, Report Finds |url=https://www.forbes.com/sites/dariosabaghi/2023/01/16/delta-8-thc-generated-2-billion-in-revenue-in-2-years-report-finds/?sh=6f49eca34a62 |work=Forbes |access-date=2 April 2023 |archive-date=2 April 2023 |archive-url=https://web.archive.org/web/20230402060526/https://www.forbes.com/sites/dariosabaghi/2023/01/16/delta-8-thc-generated-2-billion-in-revenue-in-2-years-report-finds/?sh=6f49eca34a62 |url-status=live }}</ref> Many substances are scheduled at the state level under various synonyms owing to the different dibenzopyran and monoterpenoid naming conventions. Delta-1, Delta-6, and Delta 3,4-Tetrahydrocannabinol are alternative names for Delta-9, Delta-8, and Delta-6a10a Tetrahydrocannabinol, respectively.<ref>{{Cite web |title=WHO Expert Committee on Drug Dependence Critical Review |url=https://cdn.who.int/media/docs/default-source/controlled-substances/isomersthc.pdf?sfvrsn=8d45f582_2&download=true |page=22 |access-date=2023-03-05 |archive-date=2022-06-02 |archive-url=https://web.archive.org/web/20220602175627/https://cdn.who.int/media/docs/default-source/controlled-substances/isomersthc.pdf?sfvrsn=8d45f582_2&download=true |url-status=live }}</ref>

A 2023 paper seeking the regulation of cannabinoid [[terminology]] coined the term "derived psychoactive cannabis products" to accurately and usefully distinguish said products whilst excluding unrelated substances.<ref>{{cite journal | vauthors = Rossheim ME, LoParco CR, Henry D, Trangenstein PJ, Walters ST | title = Delta-8, Delta-10, HHC, THC-O, THCP, and THCV: What should we call these products? | journal = Journal of Studies on Alcohol and Drugs | date = March 2023 | volume = 84 | issue = 3 | pages = 357–360 | pmid = 36971760 | doi = 10.15288/jsad.23-00008 | s2cid = 257552536 }}</ref>