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Clostridium perfringens
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==== Iota toxin ==== Iota toxin (ITX) is a protein produced by type E strains of ''C. perfringens.'' Iota toxins are made up of two, unlinked proteins that form a multimeric complex on cells. Iota toxins prevent the formation of filamentous actin. This causes the destruction of the cells cytoskeleton which in turn leads to the death of the cell as it can no longer maintain homeostasis.<ref>{{Cite journal |last1=Sakurai |first1=Jun |last2=Nagahama |first2=Masahiro |last3=Oda |first3=Masataka |last4=Tsuge |first4=Hideaki |last5=Kobayashi |first5=Keiko |date=2009-12-23 |title=Clostridium perfringens Iota-Toxin: Structure and Function |journal=Toxins |volume=1 |issue=2 |pages=208β228 |doi=10.3390/toxins1020208 |issn=2072-6651 |pmc=3202787 |pmid=22069542 |doi-access=free}}</ref>
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