Editing Comparative genomic hybridization (section)

====Genomic abnormalities in cancer====
Genetic alterations and rearrangements occur frequently in cancer and contribute to its pathogenesis. Detecting these aberrations by array CGH provides information on the locations of important cancer genes and can have clinical use in diagnosis, cancer classification and prognostification.<ref name="Bejjani,Shaffer" /> However, not all of the losses of genetic material are pathogenetic, since some DNA material is physiologically lost during the rearrangement of immunoglobulin subgenes. In a recent study, array CGH has been implemented to identify regions of chromosomal aberration ([[copy-number variation]]) in several mouse models of breast cancer, leading to identification of cooperating genes during myc-induced oncogenesis.<ref name="aprelikova">{{cite journal | vauthors = Aprelikova O, Chen K, El Touny LH, Brignatz-Guittard C, Han J, Qiu T, Yang HH, Lee MP, Zhu M, Green JE | title = The epigenetic modifier JMJD6 is amplified in mammary tumors and cooperates with c-Myc to enhance cellular transformation, tumor progression, and metastasis | journal = Clin Epigenetics | volume = 8 | issue = 38 | pages = 38 | date = Apr 2016 | doi = 10.1186/s13148-016-0205-6 | pmid = 27081402 | pmc = 4831179 | doi-access = free }}</ref>

Array CGH may also be applied not only to the discovery of chromosomal abnormalities in cancer, but also to the monitoring of the progression of tumors. Differentiation between [[metastatic]] and mild lesions is also possible using FISH once the abnormalities have been identified by array CGH.<ref name="deRavel,Devriendt,Fryns,Vermeesch" /><ref name="Marquis-Nicholson,Aftimos,Hayes,George,Love" />