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Delayed puberty
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=== Malnutrition or chronic disease === If the delay is due to systemic disease or [[malnutrition]], the therapeutic intervention is likely to focus direction on those conditions. In patients with [[coeliac disease]], an early diagnosis and the establishment of a [[gluten-free diet]] prevents long-term complications and allows restoration of normal maturation.<ref name="Mearin2015" /><ref name="LevyBernstein2014" /> Thyroid hormone therapy will be necessary in the case of hypothyroidism.<ref name=":0" />
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