Editing Delta wave (section)

==Pharmacology==

While most drugs that affect sleep do so by stimulating sleep onset, or disrupting REM sleep, a number of chemicals and drugs have been shown to alter delta wave activity.
* [[Delta sleep-inducing peptide]], as the name suggests, induces delta wave EEG activity.
* Alcohol reduces SWS delta wave activity, thereby restricting the release of [[growth hormone]] (GH) by the pituitary.<ref>Lands, William. "Alcohol, Slow Wave Sleep, and the Somatotropic Axis." Alcohol 18.2 (1999): 109–22.</ref>
* The muramyl peptide, [[muramyl dipeptide]] (MDP, N-acetylmuramyl-L-alanyl-D-isoglutamine) has been shown to increase delta wave activity during slow wave sleep.<ref>Davenne, D. M. "Enhancement of Quiet Sleep in Rabbit Neonates by Muramyl Dipeptide." Am J Physiol. 253.4 (1987): 646–54. Print.</ref>
* The drug [[Gabapentin]], a drug used to control epileptic seizures, increases delta-wave activity and slow wave sleep in adults.<ref>Foldvary-Schaefer, N., I. De Leon Sanchez, M. Karafa, D. Dinner, and H. H. Morris. "Gabapentin Increases Slow-wave Sleep in Normal Adults." Epilepsia 43.12 (2002): 1493–497. Print.</ref>
* While hypnotics like [[zolpidem]] increase slow wave sleep, they do not increase delta wave activity, and instead increase spindle activity during slow wave sleep.<ref name="D'haenen, H. A. H. 2002">D'haenen, H. A. H., Johan A. Den Boer, and Paul Willner. Biological Psychiatry. Chichester: Wiley, 2002. Print.</ref>
* [[Gamma-Hydroxybutyric acid|Gamma-hydroxy butyrate]] (GHB) increases delta slow-wave sleep as well as sleep-related growth hormone (GH).<ref name="D'haenen, H. A. H. 2002"/>
* Administration of high-dose [[nitrous oxide]] is associated with transient, large amplitude slow-delta oscillations.<ref>Kara J. Pavone, Oluwaseun Akeju, Aaron L. Sampson, Kelly Ling, Patrick L. Purdon, Emery N. Brown. [https://www.clinph-journal.com/article/S1388-2457(15)00629-X/fulltext Nitrous oxide-induced slow and delta oscillations]" Journal of Clinical Neurophysiology, Jan. 2016</ref>