Editing Non-coding RNA (section)

===Alzheimer's disease===

The antisense RNA, [[BACE1-AS]] is transcribed from the opposite strand to [[BACE1]] and is upregulated in patients with [[Alzheimer's disease]].<ref name="pmid18587408">{{cite journal | vauthors = Faghihi MA, Modarresi F, Khalil AM, Wood DE, Sahagan BG, Morgan TE, Finch CE, St Laurent G, Kenny PJ, Wahlestedt C | display-authors = 6 | title = Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase | journal = Nature Medicine | volume = 14 | issue = 7 | pages = 723–730 | date = July 2008 | pmid = 18587408 | pmc = 2826895 | doi = 10.1038/nm1784 }}</ref> BACE1-AS regulates the expression of BACE1 by increasing BACE1 mRNA stability and generating additional BACE1 through a post-transcriptional feed-forward mechanism. By the same mechanism it also raises concentrations of [[beta amyloid]], the main constituent of senile plaques. BACE1-AS concentrations are elevated in subjects with Alzheimer's disease and in amyloid precursor protein transgenic mice.