Editing Toothpaste (section)

===Miscellaneous issues and debates===
With the exception of toothpaste intended to be used on pets such as dogs and cats, and toothpaste used by [[astronaut]]s, most toothpaste is not intended to be swallowed, and doing so may cause [[nausea]] or [[diarrhea]]. Tartar fighting toothpastes have been debated.<ref>{{cite web|url=http://www.toxictoothpaste.org/ |archive-url=https://web.archive.org/web/20120423145344/http://www.toxictoothpaste.org/ |archive-date=2012-04-23 |title=Tartar Fighting Toothpastes & Toxic Reactions|work=toxictoothpaste.org}}</ref>  Sodium lauryl sulfate (SLS) has been proposed to increase the frequency of [[mouth ulcer]]s in some people, as it can dry out the protective layer of oral tissues, causing the underlying tissues to become damaged.<ref>[http://www.dentalgentlecare.com/cancer_sores_copy(1).htm Canker Sores] {{webarchive|url=https://web.archive.org/web/20060208030507/http://www.dentalgentlecare.com/cancer_sores_copy%281%29.htm |date=February 8, 2006 }}. Dentalgentlecare.com. Retrieved on April 4, 2013.</ref> In studies conducted by the university of Oslo on [[recurrent aphthous ulcer]]s, it was found that SLS has a denaturing effect on the oral [[Mucous membrane|mucin]] layer, with high affinity for proteins, thereby increasing epithelial permeability.<ref>{{cite journal | vauthors = Herlofson BB, Barkvoll P | title = The effect of two toothpaste detergents on the frequency of recurrent aphthous ulcers | journal = Acta Odontologica Scandinavica | volume = 54 | issue = 3 | pages = 150–3 | date = June 1996 | pmid = 8811135 | doi = 10.3109/00016359609003515 }}</ref> In a double-blind cross-over study, a significantly higher frequency of [[Aphthous stomatitis|aphthous ulcers]] was demonstrated when patients brushed with an SLS-containing versus a detergent-free toothpaste. Also patients with [[Oral lichen planus|Oral Lichen Planus]] who avoided SLS-containing toothpaste benefited.<ref>{{cite book| vauthors = Nikiforuk G |title=Understanding dental caries. prevention: basic and clinical aspects|date=1985|publisher=Karger|location=Basel|isbn=978-3-8055-3905-0 | doi = 10.1159/000409915 | pages=87–112|chapter=5 Fluoride Dentifrices and Fluoride Rinses}}</ref><ref>{{cite journal | vauthors = Barkvoll P, Rølla G | title = Triclosan protects the skin against dermatitis caused by sodium lauryl sulphate exposure | journal = Journal of Clinical Periodontology | volume = 21 | issue = 10 | pages = 717–9 | date = November 1994 | pmid = 7852618 | doi = 10.1111/j.1600-051x.1994.tb00792.x }}</ref>