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=== January–March=== * [[January 13]] – The [[Treaty of Madrid (13 January 1750)|Treaty of Madrid]] between [[Spain]] and [[Portugal]] authorizes a larger [[Brazil]] than had the [[Treaty of Tordesillas]] of [[1494]], which originally established the boundaries of the Portuguese and Spanish territories in South America. * [[January 24]] – A fire in [[Istanbul]] destroys 10,000 homes.<ref>"Fires", in ''The New International Encyclopedia'' (Volume 8) (Dodd, Mead and Company, 1915 p. 604.</ref> * [[February 15]] – After Spain and Portugal agree that the [[Uruguay River]] will be the boundary line between the two kingdoms' territory in South America, the Spanish Governor orders the Jesuits to vacate seven Indian missions along the river (San Angel, San Nicolas, San Luis, San Lorenzo, San Miguel, San Juan and San Borja).<ref>R. B. Cunninghame Graham, ''A Vanished Arcadia, being Some Account of the Jesuits in Paraguay'' (Haskell House Publishers, 1901, 1968) pp. 237-238.</ref> * [[March 5]] – The Murray-Kean Company, a troupe of actors from Philadelphia, gives the first performance of a play announced in advance in a newspaper, presenting ''Richard III'' at New York City's Nassau Street Theatre.<ref>Heather S. Nathans, ''Early American Theatre from the Revolution to Thomas Jefferson: Into the Hands of the People'' (Cambridge University Press, 2003) p. 30.</ref> * [[March 20]] – The first number of [[Samuel Johnson]]'s ''[[The Rambler]]'' appears.
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