Editing 20-Hydroxyecdysone (section)

==Ecdysteroid activity in arthropods==
In insects, an [[ecdysteroid]] is a type of [[steroid hormone]] derived from enzymatic modification of cholesterol by [[p450]] enzymes.<ref>{{cite journal | vauthors = Kamiyama T, Niwa R | title = Transcriptional Regulators of Ecdysteroid Biosynthetic Enzymes and Their Roles in Insect Development | journal = Frontiers in Physiology | volume = 13 | pages = 823418 | date = 2022 | pmid = 35211033 | pmc = 8863297 | doi = 10.3389/fphys.2022.823418 | doi-access = free }}</ref> This occurs by a mechanism similar to [[steroid synthesis]] in vertebrates.  [[Ecdysone]] and 20-hydroxyecdysone regulate larval molts, onset of [[puparium]] formation, and [[metamorphosis]]. As these hormones are hydrophobic, they traverse [[lipid membrane]]s and permeate the tissues of an organism. Indeed, the [[ecdysone receptor]] is an [[intracellular]] [[protein]].<ref name="pmid11037621">{{cite journal | vauthors = Riddiford LM, Cherbas P, Truman JW | title = Ecdysone receptors and their biological actions | journal = Vitamins and Hormones | volume = 60 | pages = 1–73 | year = 2000 | pmid = 11037621 | doi = 10.1016/S0083-6729(00)60016-X | isbn = 978-0-12-709860-9 | series = Vitamins & Hormones }}</ref>