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5-HT receptor
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===Families=== {| class="wikitable" ! Family !! Type !! Mechanism !! Potential |- | '''[[5-HT1|5-HT<sub>1</sub>]]''' || [[Gi alpha subunit|G<sub>i</sub>/G<sub>o</sub>]]-protein coupled. || Decreasing cellular levels of [[cyclic adenosine monophosphate|cAMP]]. || Inhibitory |- | '''[[5-HT2|5-HT<sub>2</sub>]]''' || [[Gq protein|G<sub>q</sub>/G<sub>11</sub>]]-protein coupled. || Increasing cellular levels of [[inositol trisphosphate|IP<sub>3</sub>]] and [[diglyceride|DAG]]. || Excitatory |- | '''[[5-HT3|5-HT<sub>3</sub>]]''' || Ligand-gated [[sodium|Na<sup>+</sup>]] and [[potassium|K<sup>+</sup>]] [[cation channel]]. || [[depolarization|Depolarizing]] [[plasma membrane]]. || Excitatory |- | '''[[5-HT4|5-HT<sub>4</sub>]]''' || [[G(s)alpha|G<sub>s</sub>]]-protein coupled. || Increasing cellular levels of [[cyclic adenosine monophosphate|cAMP]]. || Excitatory |- | '''[[5-HT5A|5-HT<sub>5</sub>]]''' || [[Gi alpha subunit|G<sub>i</sub>/G<sub>o</sub>]]-protein coupled.<ref name="pmid9865521">{{cite journal | vauthors = Francken BJ, Jurzak M, Vanhauwe JF, Luyten WH, Leysen JE | title = The human 5-ht5A receptor couples to Gi/Go proteins and inhibits adenylate cyclase in HEK 293 cells | journal = European Journal of Pharmacology | volume = 361 | issue = 2β3 | pages = 299β309 | date = November 1998 | pmid = 9865521 | doi = 10.1016/S0014-2999(98)00744-4 }}</ref> || Decreasing cellular levels of [[cyclic adenosine monophosphate|cAMP]]. || Inhibitory |- | '''[[5-HT6|5-HT<sub>6</sub>]]''' || [[G(s)alpha|G<sub>s</sub>]]-protein coupled. || Increasing cellular levels of [[cyclic adenosine monophosphate|cAMP]]. || Excitatory |- | '''[[5-HT7|5-HT<sub>7</sub>]]''' || [[G(s)alpha|G<sub>s</sub>]]-protein coupled. || Increasing cellular levels of [[cyclic adenosine monophosphate|cAMP]]. || Excitatory |- |}
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