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Amitriptyline
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===Depression=== Amitriptyline is effective for depression,<ref name="pmid23235671"/> but it is rarely used as a first-line antidepressant due to its higher toxicity in overdose and generally poorer tolerability.<ref name = "AMH">{{cite book | title = Australian Medicines Handbook | year = 2013 | publisher = The Australian Medicines Handbook Unit Trust | isbn = 978-0-9805790-9-3 | edition = 2013 | place = Adelaide | veditors = Rossi S }}</ref> It can be tried for depression as a second-line therapy, after the failure of other treatments.<ref name= top100drugs>{{cite book | vauthors = Hitchings A, Lonsdale D, Burrage D, Baker E |title=Top 100 drugs : clinical pharmacology and practical prescribing |date=2015 |isbn=978-0-7020-5516-4 |page=50|publisher=Churchill Livingstone }}</ref> For [[treatment-resistant depression|treatment-resistant]] adolescent depression<ref name="pmid25433401">{{cite journal | vauthors = Zhou X, Michael KD, Liu Y, Del Giovane C, Qin B, Cohen D, Gentile S, Xie P | title = Systematic review of management for treatment-resistant depression in adolescents | journal = BMC Psychiatry | volume = 14 | pages = 340 | date = November 2014 | pmid = 25433401 | pmc = 4254264 | doi = 10.1186/s12888-014-0340-6 | doi-access = free }}</ref> or for cancer-related depression<ref name="pmid24950919">{{cite journal | vauthors = Riblet N, Larson R, Watts BV, Holtzheimer P | title = Reevaluating the role of antidepressants in cancer-related depression: a systematic review and meta-analysis | journal = General Hospital Psychiatry | volume = 36 | issue = 5 | pages = 466β473 | date = 2014 | pmid = 24950919 | doi = 10.1016/j.genhosppsych.2014.05.010 }}</ref> amitriptyline is no better than placebo; however, the number of treated patients in both studies was small. It is sometimes used for the treatment of depression in [[Parkinson's disease]],<ref>{{cite web | url= http://www.merckmanuals.com/home/brain_spinal_cord_and_nerve_disorders/movement_disorders/parkinsons_disease.html |title= Parkinson's disease| website= merckmanuals.com| archive-url= https://web.archive.org/web/20131118154550/http://www.merckmanuals.com/home/brain_spinal_cord_and_nerve_disorders/movement_disorders/parkinsons_disease.html |archive-date=18 November 2013 | publisher= Merck Sharp & Dohme Corp.| date= August 2007| access-date= 22 December 2013}}</ref> but supporting evidence for that is lacking.<ref name="pmid22021174">{{cite journal | vauthors = Seppi K, Weintraub D, Coelho M, Perez-Lloret S, Fox SH, Katzenschlager R, Hametner EM, Poewe W, Rascol O, Goetz CG, Sampaio C | title = The Movement Disorder Society Evidence-Based Medicine Review Update: Treatments for the non-motor symptoms of Parkinson's disease | journal = Movement Disorders | volume = 26 | issue = Supply 3 | pages = S42βS80 | date = October 2011 | pmid = 22021174 | pmc = 4020145 | doi = 10.1002/mds.23884 }}</ref>
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