Editing Amphotericin B (section)

=== Antifungal ===
One of the main uses of amphotericin B is treating a wide range of systemic [[Fungal infection in animals|fungal infection]]s. Due to its extensive side effects, it is often reserved for severe infections in critically ill or [[immunocompromised]] patients. It is considered first line therapy for invasive [[mucormycosis]] infections, [[Cryptococcosis|cryptococcal meningitis]], and certain [[Aspergillosis|aspergillus]] and [[Candidiasis|candidal]] infections.<ref>{{cite book|title = Drugs Active against Fungi, Pneumocystis, and Microsporidia|isbn = 978-1-4557-4801-3|pages = 479–494.e4| vauthors = Bennett JE, Dolin R, Blaser MJ |date = 28 August 2014| publisher=Elsevier Health Sciences }}</ref><ref>{{cite journal | vauthors = Moen MD, Lyseng-Williamson KA, Scott LJ | title = Liposomal amphotericin B: a review of its use as empirical therapy in febrile neutropenia and in the treatment of invasive fungal infections | journal = Drugs | volume = 69 | issue = 3 | pages = 361–392 | date = 2012-09-17 | pmid = 19275278 | doi = 10.2165/00003495-200969030-00010 | s2cid = 34340503 }}</ref> It has been a highly effective drug for over fifty years in large part because it has a low incidence of [[Antimicrobial resistance|drug resistance]] in the pathogens it treats. This is because amphotericin B resistance requires sacrifices on the part of the pathogen that make it susceptible to the host environment, and too weak to cause infection.<ref>{{cite news|url=http://wi.mit.edu/news/archive/2013/understanding-evolution-drug-resistance-points-novel-strategy-developing-better|title=Understanding the evolution of drug resistance points to novel strategy for developing better antimicrobials| vauthors = Rura N |date=2013-10-29|access-date=2016-11-14|via=Whitehead Institute|url-status=live|archive-url=https://web.archive.org/web/20161115134239/http://wi.mit.edu/news/archive/2013/understanding-evolution-drug-resistance-points-novel-strategy-developing-better|archive-date=2016-11-15}}</ref>