Editing Bone tumor (section)

===Primary bone tumors===
Primary tumors of bone can be divided into [[benign|benign tumors]] and [[cancer]]s. Common benign bone tumors may be [[neoplasia|neoplastic]], developmental, [[Physical trauma|traumatic]], [[infection|infectious]], or [[inflammation|inflammatory]] in etiology. Some benign tumors are not true neoplasms, but rather, represent [[hamartoma]]s, namely the [[osteochondroma]]. The most common locations for many primary tumors, both benign and malignant include the distal femur and proximal tibia (around the knee joint). Examples of benign bone tumors include [[osteoma]], [[osteoid osteoma]], [[osteochondroma]], [[osteoblastoma]], [[enchondroma]], [[giant cell tumor of bone]] and [[aneurysmal bone cyst]].{{citation needed|date=June 2021}}

Malignant primary bone tumors, known as [[bone sarcoma]]s, include [[osteosarcoma]], [[chondrosarcoma]], [[Ewing sarcoma]], [[fibrosarcoma]], and other types. While malignant fibrous histiocytoma (MFH) - now generally called "[[pleomorphic undifferentiated sarcoma]]" - primary in bone is known to occur occasionally,<ref name='JeonSong'>Jeon DG, Song WS, Kong CB, Kim JR, Lee SY. MFH of Bone and Osteosarcoma Show Similar Survival and Chemosensitivity. ''Clin Orthop Rel Res'' 469;584-90.</ref> current paradigms tend to consider MFH a [[wastebasket diagnosis]], and the current trend is toward using specialized studies (i.e. [[Genetics|genetic]] and [[immunohistochemistry|immunohistochemical]] tests) to classify these undifferentiated tumors into other tumor classes. [[Multiple myeloma]] is a [[hematology|hematologic]] cancer, originating in the bone marrow, which also frequently presents as one or more bone lesions.<ref>{{cite web|url= https://www.lecturio.com/concepts/multiple-myeloma/|title= Multiple Myeloma|website= The Lecturio Medical Concept Library|access-date= 26 August 2021|archive-date= 26 July 2024|archive-url= https://web.archive.org/web/20240726175145/https://www.lecturio.com/concepts/multiple-myeloma/|url-status= live}}</ref>

[[Germ cell tumors]], including [[teratoma]], often present and originate in the midline of the sacrum, coccyx, or both. These sacrococcygeal teratomas are often relatively amenable to treatment.<ref>{{cite journal | vauthors = Maoz A, Matsuo K, Ciccone MA, Matsuzaki S, Klar M, Roman LD, Sood AK, Gershenson DM | display-authors = 6 | title = Molecular Pathways and Targeted Therapies for Malignant Ovarian Germ Cell Tumors and Sex Cord-Stromal Tumors: A Contemporary Review | journal = Cancers | volume = 12 | issue = 6 | page = 1398 | date = May 2020 | pmid = 32485873 | pmc = 7353025 | doi = 10.3390/cancers12061398 | doi-access = free }}</ref>