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Cardiac conduction system
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===Development=== {{Main|Heart development#Pacemaker and conduction system}} Embryologic evidence of generation of the cardiac conduction system illuminates the respective roles of this specialized set of cells. Innervation of the heart begins with a brain only centered [[parasympathetic]] [[cholinergic]] first order. It is then followed by rapid growth of a second order [[Sympathetic nervous system|sympathetic]] [[adrenergic]] system arising from the formation of the [[thorax|thoracic]] [[spinal ganglion|spinal ganglia]]. The third order of electrical influence of the heart is derived from the [[vagus nerve]] as the other peripheral organs form.<ref>{{cite web | url = http://www.embryology.ch/anglais/pcardio/funktion02.html | work = Human Embryology: Organogenesis: Functional development of the heart | title = Innervation of the heart|archive-url=https://web.archive.org/web/20200218164512/http://www.embryology.ch/anglais/pcardio/funktion02.html |archive-date=February 18, 2020}}</ref>
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