Editing Chromosomal inversion (section)

== History ==
The first evidence of a chromosomal inversion was found in 1921 by [[Alfred Sturtevant]] in [[Drosophila melanogaster]].<ref name=":03">{{cite journal | vauthors = Kirkpatrick M | title = How and why chromosome inversions evolve | journal = PLOS Biology | volume = 8 | issue = 9 | pages = e1000501 | date = September 2010 | pmid = 20927412 | pmc = 2946949 | doi = 10.1371/journal.pbio.1000501 | doi-access = free }}</ref> Since then, inversions have been found in a all [[eukaryote|eukaryotes]].<ref name=":1" /> When discovered by Sturtevant, inversions were regarded as areas of recombination suppression.

Originally, these inversions were noted in [[Polytene chromosome|polytene chromosomes]] within the salivary glands of heterozygous ''Drosophila melanogaster'' larvae.<ref name=":1" /> In 1970, [[Theodosius Dobzhansky]] noted that genes within an inversion had higher fitness than those that are found outside of the inversions, although this is an area that needs further study.<ref name=":23">{{cite journal | vauthors = Huang K, Rieseberg LH | title = Frequency, Origins, and Evolutionary Role of Chromosomal Inversions in Plants | journal = Frontiers in Plant Science | volume = 11 | pages = 296 | date = 2020 | pmid = 32256515 | pmc = 7093584 | doi = 10.3389/fpls.2020.00296 | doi-access = free }}</ref>

One of the more recent models of inversions is the Kirkpatrick and Barton Model (2006), which states that inversions are selectively advantageous by linking together adaptive alleles. By physically linking co-adapted variants at multiple genes into distinct versions (haplotypes) of an inversion, selection should be more efficient in driving these variants to high frequency in a population. This is in contrast to non-inverted regions, which may allow adaptive and maladaptive alleles to be carried.<ref>{{cite journal | vauthors = Huang K, Rieseberg LH | title = Frequency, Origins, and Evolutionary Role of Chromosomal Inversions in Plants | journal = Frontiers in Plant Science | volume = 11 | pages = 296 | date = 2020 | pmid = 32256515 | pmc = 7093584 | doi = 10.3389/fpls.2020.00296 | doi-access = free }}</ref>