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Cope reaction
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==Reverse reaction== The reverse or retro-Cope elimination has been reported, in which an N,N-disubstituted hydroxylamine reacts with an alkene to form a tertiary N-oxide.<ref>{{cite journal |last1=Ciganek |first1=Engelbert |last2=Read |first2=John M. |last3=Calabrese |first3=Joseph C. |title=Reverse Cope elimination reactions. 1. Mechanism and scope |journal=The Journal of Organic Chemistry |date=September 1995 |volume=60 |issue=18 |pages=5795–5802 |doi=10.1021/jo00123a013}}</ref><ref>{{cite journal |last1=Ciganek |first1=Engelbert |title=Reverse Cope elimination reactions. 2. Application to synthesis |journal=The Journal of Organic Chemistry |date=September 1995 |volume=60 |issue=18 |pages=5803–5807 |doi=10.1021/jo00123a014}}</ref> The reaction is a form of [[hydroamination]] and can be extended to the use of unsubstituted hydroxylamine, in which case [[oxime]]s are produced.<ref>{{cite journal |last1=Beauchemin |first1=André M. |last2=Moran |first2=Joseph |last3=Lebrun |first3=Marie-Eve |last4=Séguin |first4=Catherine |last5=Dimitrijevic |first5=Elena |last6=Zhang |first6=Lili |last7=Gorelsky |first7=Serge I. |title=Intermolecular Cope-Type Hydroamination of Alkenes and Alkynes |journal=Angewandte Chemie |date=8 February 2008 |volume=120 |issue=8 |pages=1432–1435 |doi=10.1002/ange.200703495|bibcode=2008AngCh.120.1432B }}</ref>
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