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Disseminated intravascular coagulation
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==Causes== DIC can occur in the following conditions:<ref name="isbn0-7216-7335-X"/><ref name=david>{{cite book|title=Davidson's Principles and Practice of Medicine|edition=19|year=2002|publisher=Churchill Livingstone|isbn=0-443-07036-9}}</ref><ref name=hoffman>{{cite book|title=Haematology: Basic Principles and Practice|edition=6|year=2012|publisher=Elsevier Saunders|isbn=978-1437729283}}</ref><ref name="isbn0-7020-2458-9">{{cite book|author1=Clark, Michael |author2=Kumar, Parveen J. |title=Clinical Medicine: A Textbook for Medical Students and Doctors|edition=4|publisher=W.B. Saunders|location=Philadelphia|year=1998|isbn=0-7020-2458-9}}</ref> * [[Cancer]]: solid [[tumor]]s and [[Tumors of the hematopoietic and lymphoid tissues|blood cancers]] (particularly [[acute promyelocytic leukemia]]) * [[Complications of pregnancy]]: [[abruptio placentae]], [[pre-eclampsia]] or [[eclampsia]], [[amniotic fluid embolism]], retained intrauterine [[fetal demise]], [[septic abortion]], [[postpartum hemorrhage]] * Massive tissue injury: [[Injury|trauma]], [[burn]], [[hyperthermia]], [[rhabdomyolysis]], surgery * [[Infection]]: [[sepsis|bacterial]] ([[Gram-negative]] or [[Gram-positive]]), [[viral disease|viral]], [[Mycosis|fungal]], or [[protozoan infection|protozoan]] * [[Transfusion reaction]]: [[ABO incompatibility]] * [[Allergic reaction|Allergic]] or [[toxicity|toxic reaction]]: [[snake venom]] * [[Hemangioma]]: [[Kasabach–Merritt syndrome]] * [[Aortic aneurysm]] [[Liver disease]], [[HELLP syndrome]], [[thrombotic thrombocytopenic purpura]], [[hemolytic uremic syndrome]], and [[malignant hypertension]] may mimic DIC but originate via other pathways.<ref>{{cite web |url=https://www.lecturio.com/concepts/disseminated-intravascular-coagulation/| title=Disseminated Intravascular Coagulation|website=The Lecturio Medical Concept Library |access-date= 12 July 2021}}</ref> It is not the same as conditions where the blood vessels leak, such as [[capillary leak syndrome]].<ref>{{cite journal |last1=Siddall |first1=E |last2=Khatri |first2=M |last3=Radhakrishnan |first3=J |title=Capillary leak syndrome: etiologies, pathophysiology, and management |journal=Kidney International |date=2017 |volume=92 |issue=1 |pages=37–46 |doi=10.1016/j.kint.2016.11.029 |pmid=28318633}}</ref>
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