Open main menu
Home
Random
Recent changes
Special pages
Community portal
Preferences
About Wikipedia
Disclaimers
Incubator escapee wiki
Search
User menu
Talk
Dark mode
Contributions
Create account
Log in
Editing
ENU
(section)
Warning:
You are not logged in. Your IP address will be publicly visible if you make any edits. If you
log in
or
create an account
, your edits will be attributed to your username, along with other benefits.
Anti-spam check. Do
not
fill this in!
==Summary of properties and advantages of ENU mutagenesis== # ENU is an alkylating agent and has preference for A->T base transversions and also for AT->GC transitions.<ref name=nolan>Nolan, P, Hugill, A & Cox, RD, 2002, p.278-89</ref> However it is also shown to cause GC->AT transitions.<ref name=coghill>Coghill, EL et al., 2002, p.255-6</ref> # It is known to induce point mutations, which implies that by mapping for the desired phenotype, the researcher can identify a single candidate gene responsible for the phenotype.<ref name=kile>Kile, BT & Hilton, DJ 2005, p.557-67</ref> # The point mutations are at approximately [[Base pair#Length measurements|1-2 Mb (Mega-base-pair)]] interval and occur at an approximate rate of 1 per 700 gametes.<ref name=davis/> # ENU targets spermatogonial stem cells.<ref name=nolan/> [[Image:Overviewfig1.jpg|right|thumb|350px|'''Figure 1:''' Overview of ENU mutagenesis screen.]]
Edit summary
(Briefly describe your changes)
By publishing changes, you agree to the
Terms of Use
, and you irrevocably agree to release your contribution under the
CC BY-SA 4.0 License
and the
GFDL
. You agree that a hyperlink or URL is sufficient attribution under the Creative Commons license.
Cancel
Editing help
(opens in new window)