Editing Effective population size (section)

== Selection effective size ==

In an idealised Wright-Fisher model, the fate of an allele, beginning at an intermediate frequency, is largely determined by selection if the [[selection coefficient]] s ≫ 1/N, and largely determined by neutral genetic drift if s ≪ 1/N. In real populations, the cutoff value of s may depend instead on local recombination rates.<ref name="Neher 2011" /><ref>{{cite journal
|title=Limits to the Rate of Adaptive Substitution in Sexual Populations|journal=PLOS Genetics|year=2012|volume=8|issue=6|pages=e1002740|doi=10.1371/journal.pgen.1002740|author1=Daniel B. Weissman |author2=Nicholas H. Barton |pmid=22685419 |pmc=3369949 |doi-access=free }}</ref> This limit to selection in a real population may be captured in a toy Wright-Fisher simulation through the appropriate choice of Ne. Populations with different selection effective population sizes are predicted to evolve profoundly different genome architectures.<ref>{{cite book|last=Lynch|first=Michael|title=The Origins of Genome Architecture |year=2007|publisher=Sinauer Associates|isbn=978-0-87893-484-3}}</ref><ref>{{cite journal|author1=Rajon, E. |author2=Masel, J. |author2-link=Joanna Masel | title = Evolution of molecular error rates and the consequences for evolvability| journal = PNAS| year=2011 |volume = 108| issue = 3| pages = 1082–1087 |doi=10.1073/pnas.1012918108| pmid = 21199946| pmc = 3024668 |bibcode=2011PNAS..108.1082R |doi-access=free }}</ref>