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Flagellin
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== Immune response == === In mammals === [[Mammal]]s often have [[immune system|acquired immune response]]s ([[T-cell]] and [[antibody]] responses)<ref name="pmid9000497">{{cite journal | vauthors = Genta RM | title = The immunobiology of Helicobacter pylori gastritis | journal = Seminars in Gastrointestinal Disease | volume = 8 | issue = 1 | pages = 2–11 | date = January 1997 | pmid = 9000497 }}</ref> to flagellated bacterium, which occur frequently to flagellar antigens. Flagellin has also been shown to directly interact with [[TLR5]] on T cells<ref>{{cite journal | vauthors = Sharma N, Akhade AS, Qadri A | title = Sphingosine-1-phosphate suppresses TLR-induced CXCL8 secretion from human T cells | journal = Journal of Leukocyte Biology | volume = 93 | issue = 4 | pages = 521–8 | date = April 2013 | pmid = 23345392 | doi = 10.1189/jlb.0712328 | doi-access = | s2cid = 21897008 }}</ref> and [[TLR11]].<ref name=pmid26859749>{{cite journal | vauthors = Hatai H, Lepelley A, Zeng W, Hayden MS, Ghosh S | title = Toll-Like Receptor 11 (TLR11) Interacts with Flagellin and Profilin through Disparate Mechanisms | journal = PLOS ONE | volume = 11 | issue = 2 | pages = e0148987 | date = 2016 | pmid = 26859749 | pmc = 4747465 | doi = 10.1371/journal.pone.0148987 | bibcode = 2016PLoSO..1148987H | doi-access = free }}</ref> Some bacteria are able to switch between multiple flagellin [[gene]]s in order to evade this response. Flagellins contain a Toll-like receptor 5 (TLR5) epitope, a region recognized by the immune receptor TLR5. There are variations in the strength of flagellin binding and its ability to activate TLR5. Flagellins can be classified into three groups based on these characteristics: silent flagellins, evaders and stimulators. Silent flagellins bind to TLR5 but do not induce signaling. Evaders are incapable of binding and, consequently, do not trigger TLR5 activation. Stimulators exhibit variable binding capabilities to TLR5 yet possess the ability to activate TLR5.<ref>DOI: 10.1126/sciimmunol.abq7001</ref> The propensity of the immune response to flagellin may be explained by two facts: * Flagellin is an extremely abundant protein in flagellated bacteria. * There exists a specific innate [[immune receptor]] that recognizes flagellin, [[Toll-like receptor]] 5 ([[TLR5]]).<ref name="pmid22279566">{{cite journal | vauthors = Kathrani A, Holder A, Catchpole B, Alvarez L, Simpson K, Werling D, Allenspach K | title = TLR5 risk-associated haplotype for canine inflammatory bowel disease confers hyper-responsiveness to flagellin | journal = PLOS ONE | volume = 7 | issue = 1 | pages = e30117 | date = 2012 | pmid = 22279566 | pmc = 3261174 | doi = 10.1371/journal.pone.0030117 | bibcode = 2012PLoSO...730117K | doi-access = free }}</ref> === In plants === In addition, a 22-amino acid sequence (flg22) of the conserved N-terminal part of flagellin is known to activate plant defence mechanisms.<ref>{{cite journal | vauthors = García AV, Hirt H | title = ''Salmonella enterica'' induces and subverts the plant immune system | journal = Frontiers in Microbiology | volume = 5 | pages = 141 | date = 2014-01-01 | pmid = 24772109 | pmc = 3983520 | doi = 10.3389/fmicb.2014.00141 | doi-access = free }}</ref> Flagellin perception in ''[[Arabidopsis thaliana]]'' functions via the receptor-like-kinase [[FLS2]] (FLAGELLIN SENSING 2).<ref>{{cite journal | vauthors = Gómez-Gómez L, Boller T | title = FLS2: an LRR receptor-like kinase involved in the perception of the bacterial elicitor flagellin in Arabidopsis | journal = Molecular Cell | volume = 5 | issue = 6 | pages = 1003–11 | date = June 2000 | pmid = 10911994 | doi = 10.1016/S1097-2765(00)80265-8 | doi-access = free }}</ref> Upon flg22 detection, FLS2 quickly binds to BAK1 (BRI1-associated kinase 1) to initiate signalling by reciprocal transphosphorylation of their kinase domains.<ref name="pmid17625569">{{cite journal | vauthors = Chinchilla D, Zipfel C, Robatzek S, Kemmerling B, Nürnberger T, Jones JD, Felix G, Boller T | title = A flagellin-induced complex of the receptor FLS2 and BAK1 initiates plant defence | journal = Nature | volume = 448 | issue = 7152 | pages = 497–500 | date = July 2007 | pmid = 17625569 | doi = 10.1038/nature05999 | bibcode = 2007Natur.448..497C | url = http://edoc.mpg.de/318857 | hdl = 11858/00-001M-0000-0012-3840-F | s2cid = 2818791 | hdl-access = free }}</ref> Both flagellin and [[UV-C]] act similarly to increase [[homologous recombination]], as demonstrated by Molinier et al 2006. Beyond this [[somatic (biology)|somatic]] effect, they found this to [[epigenetic trait|extend to subsequent generations of the plant]].<ref name="Urban-et-al-2018">{{cite journal | last1=Urban | first1=L. | last2=Chabane Sari | first2=D. | last3=Orsal | first3=B. | last4=Lopes | first4=M. | last5=Miranda | first5=R. | last6=Aarrouf | first6=J. | title=UV-C light and pulsed light as alternatives to chemical and biological elicitors for stimulating plant natural defenses against fungal diseases | journal=[[Scientia Horticulturae]] | publisher=[[Elsevier]] | volume=235 | year=2018 | issn=0304-4238 | doi=10.1016/j.scienta.2018.02.057 | pages=452–459 | s2cid=90436989}}</ref> [[Mitogen-activated-protein-kinases]] (MAPK) acts as downstream signalling compounds, leading ultimately to [[Pathogen-associated molecular pattern|PAMP]]-triggered immunity in which more than 900 genes are up-/down-regulated upon flg22 treatment.{{citation needed|date=October 2021}} Pre-stimulation with a synthetic flg22-peptide led to enhanced resistance against bacterial invaders.<ref>{{Cite journal |last1=Zipfel |first1=Cyril |last2=Robatzek |first2=Silke |last3=Navarro |first3=Lionel |last4=Oakeley |first4=Edward J. |last5=Jones |first5=Jonathan D. G. |last6=Felix |first6=Georg |last7=Boller |first7=Thomas |date=April 2004 |title=Bacterial disease resistance in Arabidopsis through flagellin perception |url=http://www.nature.com/articles/nature02485 |journal=Nature |language=en |volume=428 |issue=6984 |pages=764–767 |doi=10.1038/nature02485 |pmid=15085136 |bibcode=2004Natur.428..764Z |s2cid=4332562 |issn=0028-0836|url-access=subscription }}</ref>
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