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===Assembly software=== Originally, most large-scale DNA sequencing centers developed their own software for assembling the sequences that they produced. However, this has changed as the software has grown more complex and as the number of sequencing centers has increased. An example of such [[Sequence assembly#Programs|assembler]] ''Short Oligonucleotide Analysis Package'' developed by [[Beijing Genomics Institute|BGI]] for de novo assembly of human-sized genomes, alignment, [[Single-nucleotide polymorphism|SNP]] detection, resequencing, indel finding, and structural variation analysis.<ref name="li2010"/><ref name="ReferenceA"/><ref name="wang2008"/>
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