Editing Interactome (section)

==Size==
[[File:Yeast interactome size estimate.png|400px|right|thumb|Estimates of the yeast protein interactome. From Uetz P. & Grigoriev A, 2005.<ref name="Uetz2005">Uetz P. & Grigoriev A. (2005) The yeast interactome. In Jorde, L.B., Little, P.F.R., Dunn, M.J. and Subramaniam, S. (Eds), Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. John Wiley & Sons Ltd: Chichester, Volume 5, pp. 2033-2051</ref>]]
It has been suggested that the size of an organism's interactome correlates better than [[genome]] size with the biological complexity of the organism.<ref name="pmid18474861">{{cite journal |author=Stumpf MP |title=Estimating the size of the human interactome |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=105 |issue=19 |pages=6959–64 |date=May 2008 |pmid=18474861 |pmc=2383957 |doi=10.1073/pnas.0708078105 |author2= Thorne T |author3= de Silva E |display-authors=etal|bibcode=2008PNAS..105.6959S |doi-access=free }}</ref> Although protein–protein interaction maps containing several thousand binary interactions are now available for several species, none of them is presently complete and the size of interactomes is still a matter of debate.

===Yeast===
The yeast interactome, i.e. all protein–protein interactions among proteins of ''[[Saccharomyces cerevisiae]]'', has been estimated to contain between 10,000 and 30,000 interactions. A reasonable estimate may be on the order of 20,000 interactions. Larger estimates often include indirect or predicted interactions, often from [[affinity purification]]/[[mass spectrometry]] (AP/MS) studies.<ref name=Uetz2005 />