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Interferon beta-1a
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=== Clinically isolated syndrome === The earliest clinical presentation of relapsing-remitting multiple sclerosis is the clinically isolated syndrome (CIS), that is, a single attack of a single symptom. During a CIS, there is a subacute attack suggestive of [[demyelination]] which should be included in the spectrum of MS phenotypes.<ref>{{cite journal | vauthors = Lublin FD, Reingold SC, Cohen JA, Cutter GR, Sørensen PS, Thompson AJ, Wolinsky JS, Balcer LJ, Banwell B, Barkhof F, Bebo B, Calabresi PA, Clanet M, Comi G, Fox RJ, Freedman MS, Goodman AD, Inglese M, Kappos L, Kieseier BC, Lincoln JA, Lubetzki C, Miller AE, Montalban X, O'Connor PW, Petkau J, Pozzilli C, Rudick RA, Sormani MP, Stüve O, Waubant E, Polman CH | display-authors = 6 | title = Defining the clinical course of multiple sclerosis: the 2013 revisions | journal = Neurology | volume = 83 | issue = 3 | pages = 278–286 | date = July 2014 | pmid = 24871874 | pmc = 4117366 | doi = 10.1212/WNL.0000000000000560 }}</ref> Treatment with [[interferon]]s after an initial attack decreases the risk of developing clinical definite MS.<ref name="pmid18970977"/><ref name="pmid21205678">{{cite journal | vauthors = Bates D | title = Treatment effects of immunomodulatory therapies at different stages of multiple sclerosis in short-term trials | journal = Neurology | volume = 76 | issue = 1 Suppl 1 | pages = S14–S25 | date = January 2011 | pmid = 21205678 | doi = 10.1212/WNL.0b013e3182050388 | s2cid = 362182 }}</ref>
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