Editing Intramolecular reaction (section)

== Examples==
Many reactions in organic chemistry can occur in either an intramolecular or intermolecular senses.  Some reactions are by definition intramolecular or are only practiced intramolecularly, e.g., 
* [[Dieckmann condensation]] of diesters is the intramolecular version of [[aldol condensation]].
* [[Madelung synthesis]] of [[indole]]s
* [[Smiles rearrangement]]
* [[Hydroacylation]] is almost invariably practiced intramolecularly to produce ketones.<ref name=Willis>{{cite journal|author=Michael C. Willis|title=Transition Metal Catalyzed Alkene and Alkyne Hydroacylation|journal=[[Chem. Rev.]]|year=2009|doi=10.1021/cr900096x|volume=110|issue=2 |pages=725–748|pmid=19873977 }}</ref>
:RCHO  +  CH<sub>2</sub>=CHR'   →   RC(O)CH<sub>2</sub>CH<sub>2</sub>R'
* [[Nazarov cyclization reaction]] for the synthesis of [[cyclopentenone]]s
:[[File:Nazarov cyclization.png|center|320px|The Nazarov cyclization reaction]]
*The [[Wurtz reaction]], involving reductive coupling of alkyl halides, essentially is only useful when conducted intramolecularly.  Its utility is illustrated with the synthesis of strained rings:<ref>{{OrgSynth|first1 = Gary M.|last1 = Lampman|first2 = James C.|last2 = Aumiller|title = Bicyclo[1.1.0]butane|year = 1971|volume = 51 |pages = 55|doi = 10.15227/orgsyn.051.0055}}</ref>  
:[[File:Wurtz-reaction Bicyclobutane synthesis.svg|300px|center]]

Some transformations that are enabled or enhanced intramolecularly.  For example, the [[acyloin condensation]] of diesters almost uniquely produces 10-membered carbocycles, which are difficult to construct otherwise.<ref>{{March6th|page=1461}}</ref>  Another example is the 2+2 cycloaddition of [[norbornadiene]] to give [[quadricyclane]].
:[[File:Synthesis of quadricyclane from norbornadiene.png|350px|center]]