Editing Inverse agonist (section)

=== Ligand gated ion channel inverse agonists ===
An example of a receptor site that possesses basal activity and for which inverse agonists have been identified is the [[GABAA receptors|GABA<sub>A</sub> receptors]]. Agonists for GABA<sub>A</sub> receptors (such as [[muscimol]]) create a [[relaxant]] effect, whereas inverse agonists have [[agitation (action)|agitation]] effects (for example, [[Ro15-4513]]) or even [[convulsive]] and [[anxiogenic]] effects (certain [[beta-carboline]]s).<ref>{{cite journal|vauthors=Mehta AK, Ticku MK|date=August 1988|title=Ethanol potentiation of GABAergic transmission in cultured spinal cord neurons involves gamma-aminobutyric acid voltage-gated chloride channels|url=http://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=2457076|journal=The Journal of Pharmacology and Experimental Therapeutics|volume=246|issue=2|pages=558–64|pmid=2457076|access-date=2008-04-21|archive-date=2021-05-31|archive-url=https://web.archive.org/web/20210531145604/https://jpet.aspetjournals.org/content/246/2/558.long|url-status=live}}</ref><ref>{{cite journal|vauthors=Sieghart W|date=January 1994|title=Pharmacology of benzodiazepine receptors: an update|journal=Journal of Psychiatry & Neuroscience|volume=19|issue=1|pages=24–9|pmc=1188559|pmid=8148363}}</ref>