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Keratoconus
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== Genetics == Six genes have been found to be associated with the condition. These genes include [[ZNF469|BANP-ZNF469]], [[COL4A4]], [[FOXO1]], [[FNDC3B]], [[IMMP2L]] and [[COL5A1|RXRA-COL5A1]].<ref name=Rong2017/> Others likely also exist.<ref name=Rong2017>{{cite journal|last1=Rong|first1=SS|last2=Ma|first2=STU|last3=Yu|first3=XT|last4=Ma|first4=L|last5=Chu|first5=WK|last6=Chan|first6=TCY|last7=Wang|first7=YM|last8=Young|first8=AL|last9=Pang|first9=CP|last10=Jhanji|first10=V|last11=Chen|first11=LJ|title=Genetic associations for keratoconus: a systematic review and meta-analysis.|journal=Scientific Reports|date=4 July 2017|volume=7|issue=1|pages=4620|doi=10.1038/s41598-017-04393-2|pmid=28676647|pmc=5496893|bibcode=2017NatSR...7.4620R}}</ref> Patients with a parent, sibling, or child who has keratoconus have 15 to 67 times higher risk in developing corneal ectasia compared to patients with no affected relatives.<ref name=":1" /><ref name=":2" />
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