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Levonorgestrel
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===Birth control=== {{See also|Ethinylestradiol/levonorgestrel}} At low doses, levonorgestrel is used in [[oral contraceptive formulations|monophasic]] and [[oral contraceptive formulations|triphasic]] formulations of [[combined oral contraceptive pill]]s, with available monophasic doses ranging from 100 to 250 μg, and triphasic doses of 50 μg, 75 μg, and 125 μg.<ref name="Drugs.com" /> It is combined with the estrogen [[ethinylestradiol]] in these formulations.<ref name="Drugs.com" /> At very low daily dose of 30 μg, levonorgestrel is used in some [[progestogen-only pill]] [[oral contraceptive formulations#Progestogen-only pills|formulations]].<ref name="Drugs.com" /> Levonorgestrel is the active ingredient in a number of [[intrauterine devices]] including Mirena and Skyla.<ref name="Drugs.com" /><ref name="pmid26732558" /> It is also the active ingredient in the [[birth control implant]]s [[Norplant]] and [[Norplant|Jadelle]].<ref name="Drugs.com" /><ref name="pmid26732558" /> One of the more common forms of contraception that contains only levonorgestrel is an IUD. One IUD, the Mirena, is a small hollow cylinder containing levonorgestrel and polydimethylsiloxane and covered with a release rate-controlling membrane.<ref name="Bao Q 2018">{{cite journal | vauthors = Bao Q, Gu B, Price CF, Zou Y, Wang Y, Kozak D, Choi S, Burgess DJ | title = Manufacturing and characterization of long-acting levonorgestrel intrauterine systems | journal = International Journal of Pharmaceutics | volume = 550 | issue = 1–2 | pages = 447–454 | date = October 2018 | pmid = 30195080 | doi = 10.1016/j.ijpharm.2018.09.004 | pmc = 6622171 }}</ref>
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