Editing Lipodystrophy (section)

== Pathogenesis ==
Due to an insufficient capacity of subcutaneous [[adipose tissue|tissue]] to store fat, fat is deposited in non-adipose tissue ([[lipotoxicity]]), leading to [[insulin resistance]].<ref name="pmid31071311" /> Patients may display [[hypertriglyceridemia]], severe [[fatty liver disease]] and little or no adipose tissue.<ref name="pmid31656583">{{cite journal | vauthors=Bruder-Nascimento T, Kress TC, Belin de Chantemele EJ | title=Recent advances in understanding lipodystrophy: a focus on lipodystrophy-associated cardiovascular disease and potential effects of leptin therapy on cardiovascular function | journal=[[Faculty of 1000#F1000Research|F1000Research]] | volume=8 | pages=F1000 Faculty Rev-1756 | year=2019 |  doi = 10.12688/f1000research.20150.1 | pmc = 6798323 |  pmid=31656583 | doi-access=free }}</ref> Average patient lifespan is approximately 30 years before death, with liver failure being the usual cause of death.<ref name="pmid31656583" /> In contrast to the high levels seen in [[non-alcoholic fatty liver disease]] (NAFLD) associated with obesity, [[leptin]] levels are very low in lipodystrophy.<ref name="pmid31071311" />