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Maturation promoting factor
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== Structure == MPF is composed of two subunits: * [[Cyclin-dependent kinase 1]] (CDK1), the cyclin-dependent kinase subunit. It uses [[Adenosine triphosphate|ATP]] to phosphorylate specific [[serine]] and [[threonine]] residues of target proteins. * [[Cyclin]], a regulatory subunit. The cyclins are necessary for the kinase subunit to function with the appropriate substrate. The mitotic cyclins can be grouped as cyclins A & B. These cyclins have a nine residue sequence in the N-terminal region called the “destruction box”, which can be recognized by the ubiquitin ligase enzyme which destroys the cyclins when appropriate.
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