Editing Megaloblastic anemia (section)

== Pathophysiology ==
There is a defect in [[DNA synthesis]] in the rapidly dividing cells and to a lesser extent, [[RNA]] and [[protein synthesis]] are also impaired. Therefore, unbalanced [[Cell growth|cell proliferation]] and impaired [[cell division]] occur as a result of arrested nuclear maturation so the cells show nuclear-cytoplasmic asynchrony.

In the [[bone marrow]], most megaloblasts are destroyed prior to entering the peripheral blood ([[intramedullary]] [[hemolysis]]). Some can escape the bone marrow ([[Macrocytosis|macrocytes]]) to peripheral blood but they are destroyed by the [[Reticuloendothelial system|reticulo-endothelial system]] (extramedullary hemolysis).