Editing Mevalonate pathway (section)

==Lower mevalonate pathway==
The lower mevalonate pathway which converts (R)-[[mevalonate]] into IPP and DMAPP has 3 variants. In [[eukaryotes]], mevalonate is phosphorylated twice in the 5-OH position, then [[decarboxylated]] to yield IPP.<ref name="MIZIORKO"/> In some [[archaea]] such as ''[[Haloferax volcanii]]'', mevalonate is phosphorylated once in the 5-OH position, decarboxylated to yield isopentenyl phosphate (IP), and finally phosphorylated again to yield IPP (Archaeal Mevalonate Pathway I).<ref name="HALOFERAX"/> A third mevalonate pathway variant found in ''[[Thermoplasma acidophilum]]'', phosphorylates mevalonate at the 3-OH position followed by phosphorylation at the 5-OH position. The resulting metabolite, mevalonate-3,5-bisphosphate, is decarboxylated to IP, and finally phosphorylated to yield IPP (Archaeal Mevalonate Pathway II).<ref name="THERMOPLASMA1"/><ref name="THERMOPLASMA2"/>