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Multiple sclerosis
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===Measures of disability=== The main measure of disability and severity is the [[expanded disability status scale]] (EDSS), with other measures such as the [[multiple sclerosis functional composite]] being increasingly used in research.<ref>{{cite journal | vauthors = Kurtzke JF | author-link=John F. Kurtzke | title = Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS) | journal = Neurology | volume = 33 | issue = 11 | pages = 1444β52 | date = November 1983 | pmid = 6685237 | doi = 10.1212/WNL.33.11.1444 | doi-access = free }}</ref><ref name="pmid10467378">{{cite journal | vauthors = Amato MP, Ponziani G | title = Quantification of impairment in MS: discussion of the scales in use | journal = Multiple Sclerosis | volume = 5 | issue = 4 | pages = 216β9 | date = August 1999 | pmid = 10467378 | doi = 10.1177/135245859900500404 | s2cid = 6763447 }}</ref><ref name="pmid12356200">{{cite journal | vauthors = Rudick RA, Cutter G, Reingold S | title = The multiple sclerosis functional composite: a new clinical outcome measure for multiple sderosis trials | journal = Multiple Sclerosis | volume = 8 | issue = 5 | pages = 359β65 | date = October 2002 | pmid = 12356200 | doi = 10.1191/1352458502ms845oa | s2cid = 31529508 }}</ref> EDSS is also correlated with falls in people with MS.<ref name="Piryonesi-2021" /> While it is a popular measure, EDSS has been criticized for some of its limitations, such as overreliance on walking.<ref>{{cite journal | vauthors = van Munster CE, Uitdehaag BM | title = Outcome Measures in Clinical Trials for Multiple Sclerosis | journal = CNS Drugs | volume = 31 | issue = 3 | pages = 217β236 | date = March 2017 | pmid = 28185158 | pmc = 5336539 | doi = 10.1007/s40263-017-0412-5 }}</ref><ref name="Piryonesi-2021" />
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