Editing Myeloid sarcoma (section)

=== In acute leukemia ===
Chloromas are rare; exact estimates of their prevalence are lacking, but they are uncommonly seen even by physicians specializing in the treatment of [[leukemia]]. Chloromas may be somewhat more common in patients with the following disease features:<ref name="review">{{cite journal |vauthors=Byrd JC, Edenfield WJ, Shields DJ, Dawson NA |title=Extramedullary myeloid cell tumors in acute nonlymphocytic leukemia: a clinical review |journal=J. Clin. Oncol. |volume=13 |issue=7 |pages=1800–16 |date=July 1995 |pmid=7602369 |doi=10.1200/JCO.1995.13.7.1800 }}</ref>
* [[French–American–British classification|French–American–British (FAB) classification]] class M2
* WHO Classification (2016 revision) is a separate entity under the "Acute myeloid leukemia (AML) and related neoplasms"
* those with specific [[cytogenetics|cytogenetic]] abnormalities (e.g. t(8;21) or inv(16))
* those whose [[myeloblast]]s express [[T-cell]] surface markers, [[CD13]], or [[CD14]]
* those with high peripheral [[white blood cell]] counts

However, even in patients with the above risk factors, chloroma remains an uncommon complication of acute myeloid leukemia.

Rarely, a chloroma can develop as the sole manifestation of relapse after apparently successful treatment of acute myeloid leukemia. In keeping with the general behavior of chloromas, such an event must be regarded as an early herald of a systemic relapse, rather than as a localized process. In one review of 24 patients who developed isolated chloromas after treatment for acute myeloid leukemia, the mean interval until bone marrow relapse was 7 months (range, 1 to 19 months).<ref>{{cite journal |vauthors=Byrd JC, Weiss RB |title=Recurrent granulocytic sarcoma. An unusual variation of acute myelogenous leukemia associated with 8;21 chromosomal translocation and blast expression of the neural cell adhesion molecule |journal=Cancer |volume=73 |issue=8 |pages=2107–12 |date=April 1994 |pmid=7512442 |doi=10.1002/1097-0142(19940415)73:8<2107::AID-CNCR2820730815>3.0.CO;2-W|doi-access=free }}</ref>