Editing NMDA receptor (section)

== Structure ==

[[File:7eu7 NMDA-Rezeptor Regenbogen.png|right|thumb|Cartoon representation of the human NMDA receptor. Each subunit is individually rainbow colored.]]

Functional NMDA receptors are heterotetramers comprising different combinations of the GluN1, GluN2 (A-D), and GluN3 (A-B) subunits derived from distinct gene families (''Grin1''-''Grin3''). All NMDARs contain two of the obligatory GluN1 subunits, which when assembled with GluN2 subunits of the same type, give rise to canonical diheteromeric (''d''-) NMDARs (e.g., GluN1-2A-1-2A). Triheteromeric NMDARs, by contrast, contain three different types of subunits (e.g., GluN1-2A-1-2B), and include receptors that are composed of one or more subunits from each of the three gene families, designated ''t''-NMDARs (e.g., GluN1-2A-3A-2A).<ref>{{cite journal | vauthors = Beesley S, Kumar SS | title = The t-N-methyl-d-aspartate receptor: Making the case for d-Serine to be considered its inverse co-agonist | journal = Neuropharmacology | volume = 238 | pages = 109654 | date = November 2023 | pmid = 37437688 | doi = 10.1016/j.neuropharm.2023.109654 | doi-access = free }}</ref> There is one GluN1, four GluN2, and two GluN3 subunit encoding genes, and each gene may produce more than one splice variant.
* GluN1 – [[GRIN1]]
* GluN2
** GluN2A – [[GRIN2A]]
** GluN2B – [[GRIN2B]]
** GluN2C – [[GRIN2C]]
** GluN2D – [[GRIN2D]]
* GluN3
** GluN3A – [[GRIN3A]]
** GluN3B – [[GRIN3B]]