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Neuroblast
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===Differentiation=== Neuroblasts are mainly present as precursors of neurons during embryonic development; however, they also constitute one of the cell types involved in [[adult neurogenesis]]. Adult neurogenesis is characterized by neural stem cell differentiation and integration in the mature adult mammalian brain. This process occurs in the [[dentate gyrus]] of the hippocampus and in the [[subventricular zone]]s of the adult mammalian brain. Neuroblasts are formed when a [[neural stem cell]], which can differentiate into any type of mature neural cell (i.e. neurons, [[oligodendrocyte]]s, [[astrocyte]]s, etc.), divides and becomes a '''transit amplifying cell'''. Transit amplifying cells are slightly more differentiated than neural stem cells and can divide asymmetrically to produce postmitotic neuroblasts and glioblasts, as well as other transit amplifying cells. A neuroblast, a daughter cell of a transit amplifying cell, is initially a neural stem cell that has reached the "point of no return." A neuroblast has differentiated such that it will mature into a neuron and not any other neural cell type.<ref>{{cite book|last=Purves|first=D|title=Neuroscience |year=2007|publisher=W. H. Freeman|location=New York|isbn=978-0-87893-697-7|edition=4th|display-authors=etal}}{{page needed|date=April 2018}}</ref> Neuroblasts are being studied extensively as they have the potential to be used therapeutically to combat cell loss due to injury or disease in the brain, although their potential effectiveness is debated.
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