Editing Palmoplantar keratoderma (section)

===Diffuse===

[[Image:Palmoplantet keratoderma new photo.jpg|thumb|Diffuse palmoplantar keratoderma]]

Diffuse palmoplantar keratoderma is a type of palmoplantar keratoderma that is characterized by an even, thick, symmetric hyperkeratosis over the whole of the palm and sole, usually evident at birth or in the first few months of life.<ref name="Fitzpatrick_2003"/>{{rp|505}}  Restated, diffuse palmoplantar keratoderma is an [[autosomal dominant]] disorder in which hyperkeratosis is confined to the palms and soles.<ref name="Bolognia_2007" />  The two major types can have a similar clinical appearance:<ref name="Bolognia_2007" />
* ''Diffuse epidermolytic palmoplantar keratoderma'' (also known as "Palmoplantar keratoderma cum degeneratione granulosa Vörner", "Vörner's epidermolytic palmoplantar keratoderma", and "Vörner keratoderma"<ref name="Bolognia_2007" />) is one of the most common patterns of palmoplantar keratoderma, an autosomal dominant condition that presents within the first few months of life, characterized by a well-demarcated, symmetric thickening of palms and soles, often with a "dirty" snakeskin appearance due to underlying epidermolysis.<ref name="Fitzpatrick_2003" />{{rp|506}}
* ''Diffuse nonepidermolytic palmoplantar keratoderma'' (also known as "Diffuse orthohyperkeratotic keratoderma", "Hereditary palmoplantar keratoderma", "Keratosis extremitatum progrediens", "Keratosis palmoplantaris diffusa circumscripta", "Tylosis", "Unna–Thost disease", and "Unna–Thost keratoderma"<ref name="Bolognia_2007" />) is inherited as an autosomal dominant condition and is present from infancy, characterized by a well-demarcated, symmetric, often "waxy" [[keratoderma]] involving the whole of the palms and soles.<ref name="Fitzpatrick_2003" />{{rp|506–8}}<ref name="Andrews_2005" />{{rp|213}}