Editing Parafollicular cell (section)

===Development===
Parafollicular cells are derived from pharyngeal [[endoderm]].<ref>{{cite journal | vauthors = Nilsson M, Williams D | title = On the Origin of Cells and Derivation of Thyroid Cancer: C Cell Story Revisited | journal = European Thyroid Journal | volume = 5 | issue = 2 | pages = 79–93 | date = July 2016 | pmid = 27493881 | pmc = 4949372 | doi = 10.1159/000447333 }}</ref><ref>Johansson, E., Andersson, L., Örnros, J., Carlsson, T., Ingeson-Carlsson, C., Liang, S., … Nilsson, M. (2015). Revising the embryonic origin of thyroid C cells in mice and humans. Development, 142(20), 3519–3528. http://doi.org/10.1242/dev.126581</ref> Embryologically, they associate with the [[ultimopharyngeal body]], which is a ventral derivative of the fourth (or fifth) [[pharyngeal pouch (embryology)|pharyngeal pouch]]. Parafollicular cells were previously believed to be derived from the [[neural crest]] based on a series of experiments in quail-chick chimeras.<ref>{{cite journal | vauthors = Le Douarin N, Fontaine J, Le Lièvre C | title = New studies on the neural crest origin of the avian ultimobranchial glandular cells--interspecific combinations and cytochemical characterization of C cells based on the uptake of biogenic amine precursors | journal = Histochemistry | volume = 38 | issue = 4 | pages = 297–305 | date = March 1974 | pmid = 4135055 | doi = 10.1007/bf00496718 | s2cid = 7551942 }}</ref><ref>{{cite journal | vauthors = Barasch J, Gershon MD, Nunez EA, Tamir H, al-Awqati Q | title = Thyrotropin induces the acidification of the secretory granules of parafollicular cells by increasing the chloride conductance of the granular membrane | journal = The Journal of Cell Biology | volume = 107 | issue = 6 Pt 1 | pages = 2137–47 | date = December 1988 | pmid = 2461947 | pmc = 2115661 | doi = 10.1083/jcb.107.6.2137 }}</ref> However, lineage tracing experiments in mice revealed that parafollicular cells are derived from the endoderm origin.<ref>{{cite journal | vauthors = Johansson E, Andersson L, Örnros J, Carlsson T, Ingeson-Carlsson C, Liang S, Dahlberg J, Jansson S, Parrillo L, Zoppoli P, Barila GO, Altschuler DL, Padula D, Lickert H, Fagman H, Nilsson M | title = Revising the embryonic origin of thyroid C cells in mice and humans | journal = Development | volume = 142 | issue = 20 | pages = 3519–28 | date = October 2015 | pmid = 26395490 | pmc = 4631767 | doi = 10.1242/dev.126581 }}</ref>