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Pathogenicity island
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==Examples== *The [[P fimbriae]] island contains virulence factors such as haemolysin, pili, cytotoxic necrosing factor, and uropathogenic specific protein (USP).<ref>Nakano M. et al. 2001 [http://onlinelibrary.wiley.com/doi/10.1111/j.1574-6968.2001.tb10927.x/pdf Structural and sequence diversity of the pathogenicity island of uropathogenic Escherichia coli which encodes the USP protein]</ref> *''[[Yersinia pestis]]'' high pathogenicity island I has genes regulating iron uptake and storage. *''[[Salmonella]]'' ''SP-1'' and ''SP-2'' sites regulates bacterium's invasion and survival within host cells.<ref name="Groisman_1996"/> *''[[Rhodococcus equi]]'' virulence plasmid pathogenicity island encodes virulence factors for proliferation in macrophages. *The [[SaPI]] family of ''Staphylococcus aureus'' pathogenicity islands, mobile genetic elements, encode [[superantigens]], including the gene for [[toxic shock syndrome]] toxin, and are mobilized at high frequencies by specific [[bacteriophage]]s.<ref>{{cite journal|last=Lindsay|first=JA|author2=Ruzin, A |author3=Ross, HF |author4=Kurepina, N |author5=Novick, RP |display-authors=3|title=The gene for toxic shock toxin is carried by a family of mobile pathogenicity islands in Staphylococcus aureus.|journal=Molecular Microbiology|date=Jul 1998|volume=29|issue=2|pages=527β43|pmid=9720870|doi=10.1046/j.1365-2958.1998.00947.x|s2cid=30680160|doi-access=free}}</ref> *Phage encoded Cholera toxin of ''[[Vibrio cholerae]]'', Diphtheria toxin of ''[[Corynebacterium diphtheriae]]'', [[Neurotoxin]]s of ''[[Clostridium botulinum]]'' and Cytotoxin of ''[[Pseudomonas aeruginosa]]''.<ref name="Hacker_1997"/> *''[[Helicobacter pylori]]'' has two strains, one being more virulent than the other due to the presence of the ''Cag'' pathogenicity island.<ref name="Hacker_1997"/> *''[[Escherichia coli]]'' pathogenicity island carries genes of [[toxin]]s (e.g., [[Shiga toxin]]) in enterohemorrhagic ''E. coli'' (EHEC) strains.
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