Editing Plasma protein (section)

== Clinical significance ==
Separating [[blood serum|serum]] proteins by [[serum protein electrophoresis|electrophoresis]] is a valuable [[Diagnosis|diagnostic tool]], as well as a way to monitor [[Healing|clinical progress]]. Current research regarding [[blood plasma]] proteins is centered on performing [[proteomics]] analyses of serum/plasma in the search for [[biomarker]]s. These efforts started with [[two-dimensional gel electrophoresis]]<ref name="Anderson_1977">{{cite journal|vauthors=Anderson NL, Anderson NG|year=1977|title=High Resolution Two-Dimensional Electrophoresis of Human Plasma Proteins|journal=Proceedings of the National Academy of Sciences|volume=74|issue=12|pages=5421–5425|doi=10.1073/pnas.74.12.5421|pmc=431746|pmid=271964|bibcode=1977PNAS...74.5421A|doi-access=free}}</ref> efforts in the 1970s, and in more recent times this research has been performed using LC-[[Mass spectrometry#Tandem MS (MS.2FMS)|tandem MS]]<ref name="Adkins_2002">{{cite journal|author=Adkins JN|display-authors=etal|year=2002|title=Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry|journal=Molecular & Cellular Proteomics|volume=1|issue=12|pages=947–955|doi=10.1074/mcp.M200066-MCP200|pmid=12543931|doi-access=free}}</ref><ref>{{cite journal|last1=Malmström|first1=E|last2=Kilsgård|first2=O|last3=Hauri|first3=S|last4=Smeds|first4=E|last5=Herwald|first5=H|last6=Malmström|first6=L|last7=Malmström|first7=J|date=January 2016|title=Large-scale inference of protein tissue origin in gram-positive sepsis plasma using quantitative targeted proteomics|journal=Nat Commun|volume=7|page=10261|doi=10.1038/ncomms10261|pmc=4729823|pmid=26732734|bibcode=2016NatCo...710261M}}</ref> based [[proteomics]]. The normal laboratory value of [[serum total protein]] is around 7 g/dL.{{cn|date=May 2024}}

Scientists are able to identify blood proteins using Photo-affinity labeling, a means of using photo-reactive ligands as a labeling agent to identify targeted proteins.<ref>{{cite journal |last1=Geyer |first1=PE |last2=Kulak |first2=NA |last3=Pichler |first3=G |last4=Holdt |first4=LM |last5=Teupser |first5=D |last6=Mann |first6=M |last7=Chuang |date=November 2013 |title=Photoaffinity labeling of plasma proteins |journal= Molecules|volume= 18|issue= 11|pages= 13831–13859|doi=10.3390/molecules181113831 |pmid=24217326 |pmc=6270137 |doi-access=free}}</ref>