Editing Precocious puberty (section)

=== Central ===
If the cause can be traced to the [[hypothalamus]] or [[pituitary]], the cause is considered central. Other names for this type are ''complete'' or ''true precocious'' puberty.<ref>David Gardner, Dolores Shoback. Basic And Clinical Endocrinology. McGraw-Hill Medical; 2011. 9th Edition. Pg. 550</ref>

Causes of central precocious puberty can include:
* [[Tuber cinereum hamartoma|hypothalamic hamartoma]] produces pulsatile [[gonadotropin-releasing hormone]] (GnRH)
* [[Langerhans cell histiocytosis]]
* [[McCune–Albright syndrome]]

Central precocious puberty can also be caused by [[brain tumor]]s, infection (most commonly [[tuberculous meningitis]], especially in developing countries), trauma, [[hydrocephalus]], and [[Angelman syndrome]].<ref>{{Cite journal | last1 = Dickerman | first1 = R. D. | last2 = Stevens | first2 = Q. E. | last3 = Steide | first3 = J. A. | last4 = Schneider | first4 = S. J. | title = Precocious puberty associated with a pineal cyst: is it disinhibition of the hypothalamic-pituitary axis? | journal = Neuro Endocrinology Letters | volume = 25 | issue = 3 | pages = 173–175 | year = 2004 | pmid = 15349080}}</ref> Precocious puberty is associated with advancement in bone age, which leads to early fusion of epiphyses, thus resulting in reduced final height and short stature.<ref>{{cite journal|last1=Kumar|first1=Manoj|last2=Mukhopadhyay|first2=Satinath|last3=Dutta|first3=Deep|title=Challenges and controversies in diagnosis and management of gonadotropin dependent precocious puberty: An Indian perspective|journal=Indian Journal of Endocrinology and Metabolism|date=2015-01-15|volume=19|issue=2|pages=228–235|doi=10.4103/2230-8210.149316|pmid=25729684|pmc=4319262 |doi-access=free }}</ref>

Adrenocortical oncocytomas are rare with mostly benign and nonfunctioning tumors. There have been only three cases of functioning adrenocortical oncocytoma that have been reported up until 2013. Children with adrenocortical oncocytomas will present with "premature pubarche, clitoromegaly, and increased serum dehydroepiandrosterone sulfate and testosterone" which are some of the presentations associated with precocious puberty.<ref>{{Cite journal|last1=Subbiah|first1=Sridhar|last2=Nahar|first2=Uma|last3=Samujh|first3=Ram|last4=Bhansali|first4=Anil|date=May 2013|title=Heterosexual precocity: rare manifestation of virilizing adrenocortical oncocytoma|journal=Annals of Saudi Medicine|volume=33|issue=3|pages=294–297|doi=10.5144/0256-4947.2013.294|pmid=23793435|pmc=6078526|issn=0256-4947|quote = So far, in the pediatric age group, only three cases of functioning adrenocortical oncocytoma have been reported. We report a case of functioning adrenocortical oncocytoma in a 3 1/2-year-old female child who presented with premature pubarche, clitoromegaly, and increased serum dehydroepiandrosterone sulfate and testosterone. She was managed successfully with right adrenalectomy, and the tumor histology was consistent with adrenal oncocytoma.}}</ref><ref>{{Cite journal|last1=Santos-Silva|first1=Rita|last2=Bonito-Vítor|first2=Artur|last3=Campos|first3=Miguel|last4=Fontoura|first4=Manuel|s2cid=9961260|date=2014|title=Gonadotropin-Dependent Precocious Puberty in an 8-Year-Old Boy with Leydig Cell Testicular Tumor|journal=Hormone Research in Paediatrics|volume=82|issue=2|pages=133–137|doi=10.1159/000358084|pmid=24862970|issn=1663-2818}}</ref>

Precocious puberty in girls begins before the age of 8. The youngest mother on record is [[Lina Medina]], who gave birth at the age of either 5 years, 7 months and 17 days<ref name="Telegraph">{{cite news|title=Six decades later, world's youngest mother awaits aid|url=http://www.telegraphindia.com/1020827/asp/foreign/story_1140311.asp|work=[[The Telegraph (Kolkata)|The Telegraph]]|date=August 27, 2002|access-date=April 13, 2016|archive-url=https://web.archive.org/web/20090722030008/http://www.telegraphindia.com/1020827/asp/foreign/story_1140311.asp|archive-date=July 22, 2009|url-status=dead}}</ref> or 6 years 5 months as mentioned in another report.<ref>{{cite magazine | url=http://www.time.com/time/magazine/article/0,9171,893791,00.html | magazine=[[Time (magazine)|Time]] | title=Little Mother | date=December 16, 1957 | access-date=January 9, 2008 | archive-url=https://web.archive.org/web/20090422210901/http://www.time.com/time/magazine/article/0,9171,893791,00.html | archive-date=April 22, 2009 | url-status=dead }}</ref>

"Central precocious puberty (CPP) was reported in some patients with suprasellar [[arachnoid cysts]] (SAC), and SCFE ([[slipped capital femoral epiphysis]]) occurs in patients with CPP because of rapid growth and changes of growth hormone secretion."<ref>{{cite journal|last=Yamato|first=Fumiko|author2=Takaya, Junji |author3=Higashino, Hirohiko |author4=Yamanouchi, Yasuo |author5=Suehara, Hiroshi |author6= Kobayashi, Yohnosuke |s2cid=27162486|title=Slipped capital femoral epiphysis during the treatment of precocious puberty with a gonadotropin-releasing hormone-agonist: aetiological considerations|journal=European Journal of Pediatrics|date=March 2005|volume=164|issue=3|pages=173–174|doi=10.1007/s00431-004-1578-7|pmid=15592875}}</ref>

If no cause can be identified, it is considered [[idiopathic]] or constitutional.