Open main menu
Home
Random
Recent changes
Special pages
Community portal
Preferences
About Wikipedia
Disclaimers
Incubator escapee wiki
Search
User menu
Talk
Dark mode
Contributions
Create account
Log in
Editing
Protein engineering
(section)
Warning:
You are not logged in. Your IP address will be publicly visible if you make any edits. If you
log in
or
create an account
, your edits will be attributed to your username, along with other benefits.
Anti-spam check. Do
not
fill this in!
=== Rational design === {{main|Protein design}} In rational protein design, a scientist uses detailed knowledge of the structure and function of a protein to make desired changes. In general, this has the advantage of being inexpensive and technically easy, since [[site-directed mutagenesis]] methods are well-developed. However, its major drawback is that detailed structural knowledge of a protein is often unavailable, and, even when available, it can be very difficult to predict the effects of various mutations since structural information most often provide a static picture of a protein structure. However, programs such as [[Folding@home]] and [[Foldit]] have utilized [[crowdsourcing]] techniques in order to gain insight into the folding motifs of proteins.<ref>{{cite journal |last1=Farmer |first1=Tylar Seiya |last2=Bohse |first2=Patrick |last3=Kerr |first3=Dianne |title=Rational Design Protein Engineering Through Crowdsourcing |journal=Journal of Student Research |date=2017 |volume=6 |issue=2 |pages=31β38 |doi=10.47611/jsr.v6i2.377 |s2cid=57679002 |url=https://www.jofsr.org/index.php/path/article/view/377 |doi-access=free }}</ref> Computational protein design [[algorithm]]s seek to identify novel amino acid sequences that are low in energy when folded to the pre-specified target structure. While the sequence-conformation space that needs to be searched is large, the most challenging requirement for computational protein design is a fast, yet accurate, energy function that can distinguish optimal sequences from similar suboptimal ones.
Edit summary
(Briefly describe your changes)
By publishing changes, you agree to the
Terms of Use
, and you irrevocably agree to release your contribution under the
CC BY-SA 4.0 License
and the
GFDL
. You agree that a hyperlink or URL is sufficient attribution under the Creative Commons license.
Cancel
Editing help
(opens in new window)