Editing Pyridoxal phosphate (section)

== Role in human body==
{{Main|Vitamin B6}}

Pyridoxal phosphate has numerous roles in human body. A few examples below:
* '''[[Metabolism]] and [[biosynthesis]] of [[serotonin]]'''. Pyridoxal phosphate is a [[Cofactor (biochemistry)|cofactor]] of [[Aromatic L-amino acid decarboxylase|aromatic L-amino acids decarboxylase]]. This allows for conversion of  [[5-Hydroxytryptophan|5-hydroxytryptophan]] (5-HTP) into serotonin (5-HT). This reaction takes place in serotonergic neurons.
* '''Metabolism and biosynthesis of [[histamine]].''' Pyridoxal phosphate is a cofactor of [[Histidine decarboxylase|L-histidine decarboxylase]]. This allows for conversion of [[histidine]] into histamine. This reaction takes place in [[Golgi apparatus]] in [[mast cell]]s and in [[basophil]]s. Next, histamine is stored in granularity in mast cells as a complex with acid residues of [[heparin]] proteoglycan while in basophils as a complex with chondroitine sulfate.
* '''Metabolism and biosynthesis of [[Gamma-Aminobutyric acid|GABA]] (γ-aminobutyric acid)'''. Pyridoxal phosphate is a cofactor of glutamic acid decarboxylase (GAD). This allows for conversion of glutamate into GABA. Reaction takes place in cytoplasm of termination of GABA-ergic neurons, therefore [[Vitamin B6|vitamin B<sub>6</sub>]] deficiency may cause epileptic [[Epileptic seizure|seizures]] in children. Pyridoxal phosphate also participates in the oxidative [[Deamidation|deamination]] of GABA, where it is a cofactor of GABA aminotransferase. 
* '''Metabolism of [[ornithine]]'''. Pyridoxal phosphate is a cofactor of ornithine carboxylase.
* '''[[Transamination]].''' Pyridoxal phosphate takes part in [[decomposition]] and synthesis of [[amino acid]]s, fats, and carbohydrates, and in the biosynthesis of hormones, neurotransmitters, and heme.<ref>{{cite book |url=https://onlinelibrary.wiley.com/doi/book/10.1002/9783527619696 |title=Handbook of Dendritic Cells: Biology, Diseases, and Therapies |date=2006-02-06 |publisher=Wiley |isbn=978-3-527-31109-5 |editor-last=Lutz |editor-first=Manfred B. |edition=1 |language=en |doi=10.1002/9783527619696 |s2cid=183733461 |editor-last2=Romani |editor-first2=Nikolaus |editor-last3=Steinkasserer |editor-first3=Alexander |access-date=2023-11-21 |archive-date=2023-11-21 |archive-url=https://web.archive.org/web/20231121073310/https://onlinelibrary.wiley.com/doi/book/10.1002/9783527619696 |url-status=live }}</ref><ref>{{cite book |title=Handbook of vitamins |date=2001 |publisher=Dekker |isbn=978-0-8247-0428-5 |editor-last=Rucker |editor-first=Robert B. |edition=3. ed., rev. and expanded |series=Clinical nutrition in health and disease |location=New York, NY}}</ref>